INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15
The major target organ in paracetamol poisoning is the liver and the primary lesion is acute centrilobular hepatic necrosis. Without specific antidotal therapy, less than 10% would suffer severe liver damage but 1 to 2% will develop fulminant hepatic failure and this is often fatal. One to 2% of patients develop acute renal failure requiring dialysis. GSH precursors such as N-acetylcysteine have been found to be effective both in experimental animals and in humans N-acetylcysteine may reduce the severity of liver necrosis by directly conjugating with and/or reducing the reactive metabolite NAPQI. N-acetylcysteine has been shown to decrease the amount of paracetamol bound covalently to proteins, possibly by dissociation of the covalently bound paracetamol from proteins and or enhancing degradation of the arylated proteins. It appears to be safe to use intravenous N-acetylcysteine in these patients, and since they may benefit from this treatment, the use of N-acetylcysteine.
"Overview of Antidote Therapy for Acute Paracetamol Poisoning", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.2, Issue 6, page no.391 - 396, June-2017, Available :http://www.ijsdr.org/papers/IJSDR1706059.pdf
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Publication Details:
Published Paper ID: IJSDR1706059
Registration ID:170551
Published In: Volume 2 Issue 6, June-2017
DOI (Digital Object Identifier):
Page No: 391 - 396
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631
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