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IJSDR
INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15

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Paper Title: Formulation Development and Evaluation of Gastroretentive Floating Tablet of Captopril Using Natural and Synthetic Polymer With Comparision of Polymer Efficacy
Authors Name: Reena Thakur , Anant Jain , Rupali , Shivali Singla , Sachin Goyal
Unique Id: IJSDR1911016
Published In: Volume 4 Issue 11, November-2019
Abstract: The aim of the present work was to develop gastro-retentive floating tablets of Captopril investigate the effects of both natural and synthetic polymers retardant on in-vitro release. Captopril is an antihypertensive drug with an oral bioavailability of only 50% because of its poor absorption from lower gastrointestinal tract. The floating tablets of Captopril were prepared to increase the gastric retention, extend the drug release, improve the bioavailability of the drug, reduces drug waste, and improves solubility of drugs that are less soluble in a high pH environment. The gastro-retentive floating tablets of Captopril were formulated using natural and synthetic polymers as Chitosan, Hydroxy propyl methyl cellulose. Carbopol, and Lactose with a solution of PVP K-30 (Poly vinyl pyrrolidone) isopropyl alcohol and citric acid were used in different concentration as a channeling and chelating agent to obtain best optimized formulation. The presence of lactose in matrices containing HPMC increased the release rate of captopril. The prepared tablets were assessed for the quality control tests, for example, weight variation, hardness, friability, thickness, drug content, in vitro buoyancy studies and in vitro dissolution. The in vitro release investigation of the tablets was performed in 0.1 N HCl as a dissolution media. The results of the present study clearly indicate the floating tablet of Captopril formulated by using synthetic polymer showed better release, less toxic effects & better anti-hypertensive activity.
Keywords: Bioavailability; Gastro-retentive; Dissolution; Formulation; Gastrointestinal tract GIT; Hydroxy propyl methyl cellulose etc.
Cite Article: "Formulation Development and Evaluation of Gastroretentive Floating Tablet of Captopril Using Natural and Synthetic Polymer With Comparision of Polymer Efficacy", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.4, Issue 11, page no.97 - 104, November-2019, Available :http://www.ijsdr.org/papers/IJSDR1911016.pdf
Downloads: 000336256
Publication Details: Published Paper ID: IJSDR1911016
Registration ID:191103
Published In: Volume 4 Issue 11, November-2019
DOI (Digital Object Identifier):
Page No: 97 - 104
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631

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