IJSDR
IJSDR
INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15

Issue: March 2024

Volume 9 | Issue 3

Impact factor: 8.15

Click Here For more Info

Imp Links for Author
Imp Links for Reviewer
Research Area
Subscribe IJSDR
Visitor Counter

Copyright Infringement Claims
Indexing Partner
Published Paper Details
Paper Title: METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF GRAZOPREVIR AND ELBASVIR BY RP-HPLC METHOD
Authors Name: MOKARA LAXMI PRIYA , M.LAKSHMI PRASANNA , G SIREESHA
Unique Id: IJSDR191969
Published In: Volume 5 Issue 6, June-2020
Abstract: A simple, Accurate, precise method was developed for the simultaneous estimation of the Grazoprevir and Elbasvir in Tablet dosage form. Chromatogram was run through BDS C8 (150mm 4.6mm, 5µ). Mobile phase containing Buffer Acetonitrile and methanol in the ratio of 45:55 was pumped through column at a flow rate of 1.0 ml/min. Temperature was maintained at 30°C. Optimized wavelength for Grazoprevir and Elbasvir was 260nm. Retention time of Grazoprevir and Elbasvir were found to be 2.164min and 3.297min. %RSD of the Grazoprevir and Elbasvir were found to be 0.4 and 0.5 respectively. %Recover was Obtained as 99.99% and 99.58% for Grazoprevir and Elbasvir. LOD, LOQ values were obtained from regression equations of Grazoprevir and Elbasvir were 0.30ppm, 0.92ppm and 0.21ppm, 0.63ppm respectively. Regression equation of Grazoprevir y= 12298x+1919 and of Elbasvir is y = 20859x + 2050. Retention times are decreased and that run time was decreased so the method developed was simple and economical that can be adopted in regular Quality control test in Industries
Keywords: GRAZOPREVIR ELBASVIR RP-HPLC
Cite Article: "METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF GRAZOPREVIR AND ELBASVIR BY RP-HPLC METHOD", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.5, Issue 6, page no.1 - 116, June-2020, Available :http://www.ijsdr.org/papers/IJSDR191969.pdf
Downloads: 000336256
Publication Details: Published Paper ID: IJSDR191969
Registration ID:191969
Published In: Volume 5 Issue 6, June-2020
DOI (Digital Object Identifier):
Page No: 1 - 116
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631

Click Here to Download This Article

Article Preview

Click here for Article Preview







Major Indexing from www.ijsdr.org
Google Scholar ResearcherID Thomson Reuters Mendeley : reference manager Academia.edu
arXiv.org : cornell university library Research Gate CiteSeerX DOAJ : Directory of Open Access Journals
DRJI Index Copernicus International Scribd DocStoc

Track Paper
Important Links
Conference Proposal
ISSN
DOI (A digital object identifier)


Providing A digital object identifier by DOI
How to GET DOI and Hard Copy Related
Open Access License Policy
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Creative Commons License
This material is Open Knowledge
This material is Open Data
This material is Open Content
Social Media
IJSDR

Indexing Partner