A NOVEL APPROACH TOWARDS GASTRORETENTIVE DRUG DELIVERY SYSTEM
Vaishali K. Ghume
, A.R. Golhar , Dr. A.N. Merekar , Prof. M.D. Dokhe
Gastroretentive, Floating drug delivery system, Various approaches, Applications
Gastro-retentive drug delivery system is an approach to prolong the GRT, thereby targeting site-specific drug release in the upper gastrointestinal tract (GIT) for local or systemic effect. Conventional oral dosage forms possess low bioavailability problems because of their quick gastric transition from the stomach, particularly in case of drugs that are less soluble at an alkaline pH of the intestine. Also, drugs that produce their local action in the stomach get quickly emptied and don’t get sufficient residence time in the stomach. Several efforts have been made to extend the retention time of drug delivery system to reduce the frequency of dose administration. The purpose of writing this review on gastroretentive drug delivery systems was to compile the recent literature with special focus on various gastroretentive approaches that have recently become leading methodologies in the field of site-specific orally administered controlled release drug delivery. In order to understand various physiological difficulties to achieve gastric retention, we have summarized important factors controlling gastric retention. Afterwards, we have reviewed various gastroretentive approaches designed and developed until now, i.e. high density (sinking), floating, bio- or mucoadhesive, expandable, unfoldable, super porous hydrogel systems. Finally, advantages and evaluation parameters of gastroretentive drug delivery systems were covered in detail.
"A NOVEL APPROACH TOWARDS GASTRORETENTIVE DRUG DELIVERY SYSTEM", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.5, Issue 5, page no.392 - 404, May-2020, Available :https://ijsdr.org/papers/IJSDR2005062.pdf
Volume 5
Issue 5,
May-2020
Pages : 392 - 404
Paper Reg. ID: IJSDR_191814
Published Paper Id: IJSDR2005062
Downloads: 000347304
Research Area: Engineering
Country: -, -, -
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
