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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | A NOVEL APPROACH TOWARDS GASTRORETENTIVE DRUG DELIVERY SYSTEM |
| Authors Name: | Vaishali K. Ghume , A.R. Golhar , Dr. A.N. Merekar , Prof. M.D. Dokhe |
| Unique Id: | IJSDR2005062 |
| Published In: | Volume 5 Issue 5, May-2020 |
| Abstract: | Gastro-retentive drug delivery system is an approach to prolong the GRT, thereby targeting site-specific drug release in the upper gastrointestinal tract (GIT) for local or systemic effect. Conventional oral dosage forms possess low bioavailability problems because of their quick gastric transition from the stomach, particularly in case of drugs that are less soluble at an alkaline pH of the intestine. Also, drugs that produce their local action in the stomach get quickly emptied and don’t get sufficient residence time in the stomach. Several efforts have been made to extend the retention time of drug delivery system to reduce the frequency of dose administration. The purpose of writing this review on gastroretentive drug delivery systems was to compile the recent literature with special focus on various gastroretentive approaches that have recently become leading methodologies in the field of site-specific orally administered controlled release drug delivery. In order to understand various physiological difficulties to achieve gastric retention, we have summarized important factors controlling gastric retention. Afterwards, we have reviewed various gastroretentive approaches designed and developed until now, i.e. high density (sinking), floating, bio- or mucoadhesive, expandable, unfoldable, super porous hydrogel systems. Finally, advantages and evaluation parameters of gastroretentive drug delivery systems were covered in detail. |
| Keywords: | Gastroretentive, Floating drug delivery system, Various approaches, Applications |
| Cite Article: | "A NOVEL APPROACH TOWARDS GASTRORETENTIVE DRUG DELIVERY SYSTEM", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.5, Issue 5, page no.392 - 404, May-2020, Available :http://www.ijsdr.org/papers/IJSDR2005062.pdf |
| Downloads: | 000337072 |
| Publication Details: | Published Paper ID: IJSDR2005062 Registration ID:191814 Published In: Volume 5 Issue 5, May-2020 DOI (Digital Object Identifier): Page No: 392 - 404 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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