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International Journal of Scientific Development and Research - IJSDR
(An International Open Access Journal)
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2455-2631


Issue: July 2021

Volume 6 | Issue 7

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Paper Title: Development and validation of area under curve method for simultaneous estimation of clobetasol propionate and fusidic acid in cream
Authors Name: Mohapatra Deepali Pratapkumar , Dr. Alisha Patel
Unique Id: IJSDR2106008
Published In: Volume 6 Issue 6, June-2021
Abstract: A simple, specific, accurate and precise Area Under Curve spectrophotometric method was developed and validated for simultaneous estimation of Clobetasol propionate and Fusidic acid in cream. The linearity range was found to be 0.5- 2.5 μg/ml for Clobetasol propionate and 20-100 μg/ml for Fusidic acid. The co-relation co-efficient was found to be 0.9983, 0.9992 and 0.9989 ,0.9983 for Clobetasol propionate and Fusidic acid at λ1 233.00 -241.00 nm and λ2 220.00 – 228.00 nm respectively. The % recovery were found to be 99.71- 100.57 , 99.38- 100.45 and 99.65- 100.51 , 98.648-99.859 for Clobetasol propionate and Fusidic acid at λ1 233.00 -241.00 nm and λ2 220.00 – 228.00 nm respectively. Intraday precision were found to be 0.11-0.13, 0.19-0.24 and 0.29-0.31, 0.21-0.27 % RSD for Clobetasol propionate and Fusidic acid at λ1 233.00 -241.00 nm and λ2 220.00 – 228.00 nm and Interday precision were found to be within the range.
Keywords: Clobetasol propionate, Fusidic acid, Area Under Curve, UVSpectroscopy method, Validation
Cite Article: "Development and validation of area under curve method for simultaneous estimation of clobetasol propionate and fusidic acid in cream", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.6, Issue 6, page no.47 - 62, June-2021, Available :http://www.ijsdr.org/papers/IJSDR2106008.pdf
Downloads: 00025284
Publication Details: Published Paper ID: IJSDR2106008
Registration ID:193385
Published In: Volume 6 Issue 6, June-2021
DOI (Digital Object Identifier):
Page No: 47 - 62
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631

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