A BRIEF REVIEW ON PRURITUS IN CHOLESTASIS
Nishita Prajapati
, Dhruvi Patel , Pinki Purohit , Anali Patel , Nikita Champaneri
Pruritus, Cholestasis, sclerosing cholangitis, prurigo nodularis
Pruritus is an enfeeble symptom in those patients having cholestatic liver disease, including primary sclerosing cholangitis, primary biliary cirrhosis, and intrahepatic cholestasis of pregnancy. Various factors are involved in the occurrence of pruritus, such as its appearance varies from patient to patient, it will be intermittent or persistent, generalized or localized to specific parts of the body like toes and palm. Based on the etiology of cholestasis, antihistamines show unresponsive effects in patients with Cholestasis pruritus and can lead to sleep deprivation, lack of attention, and prurigo nodularis due to scratching. In severe cases of cholestasis pruritus, suicidal ideations may develop, and pruritus becomes the primary indication for liver transplantation. Cholestasis-associated pruritus also shows a diurnal rhythm having a peak intensity at late evening and an early night. The peripheral and central neurological systems have been linked to the mechanism of pruritus, leading to the development of several treatment alternatives. Most of these treatments have little evidence of efficacy at this time, indicating that more research is needed. The following review scrutinizes the current literature on epidemiology, pathogenesis, and treatment of Pruritus in Cholestasis.
"A BRIEF REVIEW ON PRURITUS IN CHOLESTASIS", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.6, Issue 11, page no.21 - 26, November-2021, Available :https://ijsdr.org/papers/IJSDR2111007.pdf
Volume 6
Issue 11,
November-2021
Pages : 21 - 26
Paper Reg. ID: IJSDR_193699
Published Paper Id: IJSDR2111007
Downloads: 000347203
Research Area: Engineering
Country: -, -, --
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
