International Journal of Scientific Development and Research - IJSDR
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Volume 7 | Issue 1

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Authors Name: Nishita Prajapati , Dhruvi Patel , Pinki Purohit , Anali Patel , Nikita Champaneri
Unique Id: IJSDR2111007
Published In: Volume 6 Issue 11, November-2021
Abstract: Pruritus is an enfeeble symptom in those patients having cholestatic liver disease, including primary sclerosing cholangitis, primary biliary cirrhosis, and intrahepatic cholestasis of pregnancy. Various factors are involved in the occurrence of pruritus, such as its appearance varies from patient to patient, it will be intermittent or persistent, generalized or localized to specific parts of the body like toes and palm. Based on the etiology of cholestasis, antihistamines show unresponsive effects in patients with Cholestasis pruritus and can lead to sleep deprivation, lack of attention, and prurigo nodularis due to scratching. In severe cases of cholestasis pruritus, suicidal ideations may develop, and pruritus becomes the primary indication for liver transplantation. Cholestasis-associated pruritus also shows a diurnal rhythm having a peak intensity at late evening and an early night. The peripheral and central neurological systems have been linked to the mechanism of pruritus, leading to the development of several treatment alternatives. Most of these treatments have little evidence of efficacy at this time, indicating that more research is needed. The following review scrutinizes the current literature on epidemiology, pathogenesis, and treatment of Pruritus in Cholestasis.
Keywords: Pruritus, Cholestasis, sclerosing cholangitis, prurigo nodularis
Cite Article: "A BRIEF REVIEW ON PRURITUS IN CHOLESTASIS", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.6, Issue 11, page no.21 - 26, November-2021, Available :http://www.ijsdr.org/papers/IJSDR2111007.pdf
Downloads: 00075628
Publication Details: Published Paper ID: IJSDR2111007
Registration ID:193699
Published In: Volume 6 Issue 11, November-2021
DOI (Digital Object Identifier):
Page No: 21 - 26
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631

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