International Journal of Scientific Development and Research - IJSDR
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Authors Name: Abhila V Mukund , Dr. Ann Rose Augusthy , Dr. Vipin K V , Duniya Asokan , Swathy K K
Unique Id: IJSDR2111009
Published In: Volume 6 Issue 11, November-2021
Abstract: The study aimed to formulate and evaluate a biodegradable in situ gel of an antibacterial drug for controlled ocular drug delivery. Ciprofloxacin hydrochloride is a broad-spectrum antibiotic used in the treatment of corneal ulceration and ocular infections. Even though drug instillation into the eye by using conventional methods is easy these have certain disadvantages like rapid dilution and washout (due to the presence of tear) which leads to poor retention time of drug in the eye. To overcome these disadvantages an in situ gelling system can be designed. Here we can overcome these disadvantages of conventional drug administration and also, we can retain a higher drug concentration in the eye for a longer period of time. The in situ gel formulated will be in a liquid state once instilled into the eye it is transformed into gel. This transition is due to the presence of thermosensitive polymers added in the formulation. Here two different variants of thermosensitive polymers poloxamer namely, poloxamer 188 and poloxamer 407 have been used in the ratio 15:23 to obtain a sustained drug release from the in situ formed in the eye. Further HPMC K4M and chitosan in ratio 1:1 was added to the formulation to control the burst release and to obtain a controlled ocular delivery. The final formulation selected with optimum controlled release was subjected to evaluation such as clarity, pH, thermosensitive evaluations, viscosity, drug content, drug entrapment efficiency, and in-vitro drug release study. From the evaluation of results, it could be concluded that the final formulation FRP-II was able to pass all the evaluation tests and could sustain the drug release upto a period of 7hr. The results of kinetic study revealed that the formulation has non-fickian diffusion-controlled drug release. From the results of accelerated stability studies, the batch was found to be stable. So, it can be concluded that a combination of poloxamer 188 and 407 along with rate controlling polymers HPMC K4M and chitosan can be successfully used to formulate in situ gel system of Ciprofloxacin hydrochloride for controlled ocular drug delivery.
Keywords: in situ gel, poloxamer 407, poloxamer 188, sol-gel transition
Cite Article: "FORMULATION AND EVALUATION OF A BIODEGRADABLE IN SITU GEL OF AN ANTIBACTERIAL DRUG FOR CONTROLLED OCULAR DRUG DELIVERY", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.6, Issue 11, page no.32 - 40, November-2021, Available :http://www.ijsdr.org/papers/IJSDR2111009.pdf
Downloads: 00075628
Publication Details: Published Paper ID: IJSDR2111009
Registration ID:193697
Published In: Volume 6 Issue 11, November-2021
DOI (Digital Object Identifier):
Page No: 32 - 40
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631

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