Head and Neck Lymphatic Obstruction and Dysphagia Following Chemo-radiotherapy for Head and Neck Cancer A Retrospective, Linear, and Experimental Research
Dr. Tshetiz Dahal
, Anusiyan Alagan , Subarna Rizal , Manoj Kharka
Head and Neck Cancer, Radiotherapy, Lymphoedema, Dysphagia, Deglutition, Deglutition disorders, Swallowing, Chemotherapy, Radiotherapy, Speech pathology, Lymphatic obstruction
The study's objectives were to investigate (a) the development of external and internal head and neck lymphoedema (HNL) in head and neck cancer (HNC) patients up to 12 months after chemo-radiotherapy (CRT), and (b) the association between HNL and swallowing performance. External/internal HNL and swallowing were assessed in 33 patients using a prospective longitudinal cohort study at 3, 6, and 12 months after CRT. Using the MD Anderson Cancer Center Lymphoedema Rating Scale and the Assessment of Lymphoedema of the Head and Neck, external HNL was evaluated. Using Patterson's Radiotherapy Oedema Rating Scale, internal HNL was evaluated. Clinical, instrumental, and patient-reported assessments were used to evaluate swallowing. Multi-variable regression models were used to evaluate the relationships between HNL and swallowing. External HNL was prevalent at 3 months (71%), improved by 6 months (58%) and largely resolved by 12 months (10%). In contrast, moderate/severe internal HNL was prevalent at 3 months (96%), 6 months (84%) and at 12 months (65%). More severe penetration/aspiration and increased diet modification were associated with higher severities of external HNL (p=0.006 and p=0.031, respectively) and internal HNL (p<0.001 and p=0.007, respectively), and more diffuse internal HNL (p=0.043 and p=0.001, respectively). Worse patient-reported swallowing outcomes were associated with a higher severity of external HNL (p=0.001) and more diffuse internal HNL (p=0.002). External HNL largely resolves by 12 months post CRT, but internal HNL persists. Patients with a higher severity of external and/or internal HNL and those with more diffuse internal HNL can be expected to have more severe dysphagia.
"Head and Neck Lymphatic Obstruction and Dysphagia Following Chemo-radiotherapy for Head and Neck Cancer A Retrospective, Linear, and Experimental Research", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.7, Issue 11, page no.224 - 235, November-2022, Available :https://ijsdr.org/papers/IJSDR2211037.pdf
Volume 7
Issue 11,
November-2022
Pages : 224 - 235
Paper Reg. ID: IJSDR_202492
Published Paper Id: IJSDR2211037
Downloads: 000347190
Research Area: Medical Science
Country: Gangtok, Sikkim, India
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
