Formulation of Gastroretentive Floating Tablet Using Cross-linked Sterculia foetida gum
Lokesh P. Kothari
, Dr. Atish S. Mundada
Sterculia foetida gum (SFG), floating drug delivery system (FDDS), Diltiazem hydrochloride (DH), Buoyancy lag time (BLT), full factorial design etc.
Semi synthetic or Natural materials have been gaining lot of interest in the field of drug delivery as they are readily available, cost effective, eco-friendly and compatible due to their natural origin. The purpose of the present research was to develop gastroretentive floating tablets of Diltiazem hydrochloride using modified Sterculia foetida gum. Physicochemical characterization like Viscosity, pH, X-ray diffraction of modified SFG was done. A 32 full factorial design (nine runs) was utilized to optimize the formulation wherein the concentration of modified SFG (X1) and concentration of effervescent agent(X2) were taken as independent variables and Cumulative % drug release upto 12hr (Y1) and buoyancy lag time (BLT) (Y2) were taken as dependant variables. The quantitative, as well as qualitative influence of factor on the response, was thoroughly investigated using Design Expert® software (version 13; Stat-Ease, Inc., Minneapolis, MN, USA).. Software generated polynomial equations were utilized to understand the significant interaction among the factors and responses. The Optimized formulations of the tablets were compared with the tablets prepared with natural SFG. The results revealed that, the modified SFG gum has higher drug release retarding capacity than that of natural SFG. The FTIR results indicated that there were no interactions of modified SFG with Diltiazem hydrochloride. It can be concluded from the outcome of the present investigation that modified SFG has good potentials for formulating gastroretentive floating drug delivery system.
"Formulation of Gastroretentive Floating Tablet Using Cross-linked Sterculia foetida gum", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.7, Issue 11, page no.790 - 801, November-2022, Available :https://ijsdr.org/papers/IJSDR2211110.pdf
Volume 7
Issue 11,
November-2022
Pages : 790 - 801
Paper Reg. ID: IJSDR_202682
Published Paper Id: IJSDR2211110
Downloads: 000347274
Research Area: Pharmacy
Country: Dist-Nasik, Maharashtra, India
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
