IJSDR
IJSDR
INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15

Issue: March 2024

Volume 9 | Issue 3

Impact factor: 8.15

Click Here For more Info

Imp Links for Author
Imp Links for Reviewer
Research Area
Subscribe IJSDR
Visitor Counter

Copyright Infringement Claims
Indexing Partner
Published Paper Details
Paper Title: Formulation and Evaluation of floating matrix tablet captopril
Authors Name: Mr.Sagar R.Koli , Mr.Chandranil D.Ishi , Mr.Mahesh P. Pawar
Unique Id: IJSDR2211169
Published In: Volume 7 Issue 11, November-2022
Abstract: The present study involves preparation and evaluation of floating matrix tablet of Captopril as model drug for prolongation of gastric residence time. The tablets were prepared by Direct compression method using polymers HPMC (K4M), HPMC (K4M), Xantham gum and Guar gum. The tablet were evaluated for angle of repose, bulk density, tapped density, carr’s index, hausner’s ratio. The prepared tablets were characterized by hardness, thickness, friability, weight variation and drug content respectively. In-vitro drug release studies were performed by using an USP dissolution test apparatus (Basket type II) at 37±0.5ºC and 50 rpm speed. To study the release behavior, kinetic analyses were performed on the optimized formulation. The dissolution data were fitted to zero order, first order, matrix, Hixson-Crowell, Peppas model. The prepared tablet exhibited prolonged drug release (~ 12 h) and remained buoyant for > 12 h. The optimized formulations F13 were kept for short term stability study. The conditions for stability study were 40ºC and relative humidity of 75% from the study; it was observed that there is no significant change in stability and drug release rate.
Keywords: Floating matrix tablet, Captopril, In-vitrorelease.
Cite Article: "Formulation and Evaluation of floating matrix tablet captopril", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.7, Issue 11, page no.1126 - 1154, November-2022, Available :http://www.ijsdr.org/papers/IJSDR2211169.pdf
Downloads: 000336256
Publication Details: Published Paper ID: IJSDR2211169
Registration ID:202780
Published In: Volume 7 Issue 11, November-2022
DOI (Digital Object Identifier):
Page No: 1126 - 1154
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631

Click Here to Download This Article

Article Preview

Click here for Article Preview







Major Indexing from www.ijsdr.org
Google Scholar ResearcherID Thomson Reuters Mendeley : reference manager Academia.edu
arXiv.org : cornell university library Research Gate CiteSeerX DOAJ : Directory of Open Access Journals
DRJI Index Copernicus International Scribd DocStoc

Track Paper
Important Links
Conference Proposal
ISSN
DOI (A digital object identifier)


Providing A digital object identifier by DOI
How to GET DOI and Hard Copy Related
Open Access License Policy
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Creative Commons License
This material is Open Knowledge
This material is Open Data
This material is Open Content
Social Media
IJSDR

Indexing Partner