INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15
Formulation and Evaluation of floating matrix tablet captopril
Authors Name:
Mr.Sagar R.Koli
, Mr.Chandranil D.Ishi , Mr.Mahesh P. Pawar
Unique Id:
IJSDR2211169
Published In:
Volume 7 Issue 11, November-2022
Abstract:
The present study involves preparation and evaluation of floating matrix tablet of Captopril as model drug for prolongation of gastric residence time. The tablets were prepared by Direct compression method using polymers HPMC (K4M), HPMC (K4M), Xantham gum and Guar gum. The tablet were evaluated for angle of repose, bulk density, tapped density, carr’s index, hausner’s ratio. The prepared tablets were characterized by hardness, thickness, friability, weight variation and drug content respectively. In-vitro drug release studies were performed by using an USP dissolution test apparatus (Basket type II) at 37±0.5ºC and 50 rpm speed. To study the release behavior, kinetic analyses were performed on the optimized formulation. The dissolution data were fitted to zero order, first order, matrix, Hixson-Crowell, Peppas model. The prepared tablet exhibited prolonged drug release (~ 12 h) and remained buoyant for > 12 h. The optimized formulations F13 were kept for short term stability study. The conditions for stability study were 40ºC and relative humidity of 75% from the study; it was observed that there is no significant change in stability and drug release rate.
"Formulation and Evaluation of floating matrix tablet captopril", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.7, Issue 11, page no.1126 - 1154, November-2022, Available :http://www.ijsdr.org/papers/IJSDR2211169.pdf
Downloads:
000336256
Publication Details:
Published Paper ID: IJSDR2211169
Registration ID:202780
Published In: Volume 7 Issue 11, November-2022
DOI (Digital Object Identifier):
Page No: 1126 - 1154
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631
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