Preparation and Evaluation of Sunscreen Containing Microspheres of Resveratrol

Rahul Jodh , Pravin Kawtikwar , Ankita Kawtikwar

Resveratrol, Sunscreen, Microspheres, Antioxidants, UV Radiations

The objective of the current study was to formulate and evaluate the sunscreen loaded with microspheres of resveratrol. The method used for the preparation of microspheres was solvent evaporation method. Eudragit was used as a polymer for the coating of the drug and ethanol: dichloromethane were used as the solvent.The pure drug was highly compatible with the polymers in various ratios. The percent drug entrapment in the prepared ratios was found to be 58.07±1.02%, the percent drug release from in-vitro study was found to be 99.08% while the percent drug release from the ex-vivo study was found to be 98.47% in 12hrs. From the histopathological study it was seen that the prepared cream formulation was found to be safe for the use with good sun protective activity. The sun screen efficiency and in-vitro SPF study revealed that the prepared formulation was having a maximum absorbance of 2.432nm with the SPF value of 3.909257.The photostability study of the cream suggested the results that the prepared cream was stable and the unstable product started to degrade as soon as exposed to the sun while the batchA5 can provide a better UV protection with a stable sunscreen product. From the kinetics study it was revealed that the formulation shows a zero order drug release with a mechanism of Korsmeyers peppas modelfollowed by super case –II transport. The product was tested under the stability study and was found that the changes were not significant. The prepared microspheres were having a good sun protective action and is also safe on skin with higher stability.

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"Preparation and Evaluation of Sunscreen Containing Microspheres of Resveratrol ", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.7, Issue 12, page no.280 - 290, December-2022, Available :https://ijsdr.org/papers/IJSDR2212048.pdf

Volume 7 Issue 12, December-2022

Pages : 280 - 290

Paper Reg. ID: IJSDR_202952

Published Paper Id: IJSDR2212048

Downloads: 000347752

Research Area: Pharmacy

Country: Pusad, Maharashtra, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2212048

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2212048

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

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