DEVELOPMENT AND CHERECTERIZATION OF PULSATILE RELEASE TABLET OF NIZATIDINE

Mr. Chandranil D.ishi , Mr.Sagar R.Koli , Mr. Mahesh P. Pawar

formulation of nizatidine, superdistigrantcrosspovidone, cross croscarmellose Sodium, Hydroxy propyl methyl cellulose HPMC, evaluation, pulsatile release tablet

The objectives of pulsatile release tablet of nizatidine are pulsatile.it is inhibit the peptic secretion. The core tablets containing Nizatidine (150 mg/per tablet), lactose, microcrystalline cellulose (Avicel®PH101), polyvinyl pyrrolidone (PVP K30) and superdisintegrant like crosspovidone, croscarmellose sodium (Ac-Di-Sol®) sodium starch glycolate, were prepared by direct compression. Initially, the core tablet excipients were dry blended in polybags for 10min, followed by the addition of Talc,magnesium stearate and Aerosil ® 200.The powder components were further blended for 5min.The core tablets (diameter, 9mm; biconvex; average tablet weight, 360mg) were compressed using a Eight station tablet machine (karnavati, Ahmadabad, India). Nizatidine was observed to be almost white buff crystalline powder, sulphurmercaptonodour with metallic bitter test. The results are. The melting point was found to be 131-134°C.The solubility studies of Nizatidine were performed in various solvents. The Nizatidine was to be freely soluble in chloroform, in methanol soluble in water and buffered solution slightly soluble in ethyl acetate and isopropanol. The melting was observed at 131-134°c.The DSC curve of pure Nizatidine exhibited a single endothermic responses corresponding to the melting of drug. Onset of melting was obtained at 135°c.The superdisintegrantcroscarmellose sodium, crosspovidone, sodium starch glycolate shows broad endothermic fusion peaks at 96.11°c, 94.96°c and 84.48°c respectively which is due to glass transition state. The DSC spectra of physical mixture of Nizatidine and mixture of other excipients has also shown same endothermic peak like pure drug .These observations of DSC study indicate absence of significant interaction between drug and excipients used in tablets formulation.

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"DEVELOPMENT AND CHERECTERIZATION OF PULSATILE RELEASE TABLET OF NIZATIDINE", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.7, Issue 12, page no.294 - 341, December-2022, Available :https://ijsdr.org/papers/IJSDR2212050.pdf

Volume 7 Issue 12, December-2022

Pages : 294 - 341

Paper Reg. ID: IJSDR_202954

Published Paper Id: IJSDR2212050

Downloads: 000347236

Research Area: Pharmacy

Country: Dhule, Maharashtra, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2212050

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2212050

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

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