Green Synthesis and Docking Studies of Novel Coupled chromonyl thiadiazolyl Derivatives by Kabachnik - Fields reaction

VAISHNAVI KIRAN CHIVTE , DHANASHREE KIRAN CHIVTE

Kabachnik-Fields reaction; Ultrasound, thiadiazol; 3-formyl chromone; α-amino phosphonate; zirchonium oxychloride

The work reports facile synthesis of novel ten α-aminophosphonate derivatives coupled with 3-formyl chromone moiety, namely diethyl ((4-oxo-4H-chromen-3-yl)((5-sustituted phenyl-1,3,4-thiadiazol-2-yl)amino)methyl)phosphonate 6(a-j). The derivatives 6(a-j) were synthesized through one-pot three component Kabachnik-Fields reaction, by using ultrasound in presence of zirconium oxychloride (ZrOCl2) as a catalyst, to give the final compounds in better yields and in shorter reaction time. Thiadiazole and its derivatives possess a broad range of biological and pharmacological properties. 5-substituted phenyl-1,3,4-thiadiazol-2-amine is widely used as starting material for the synthesis of a broad range of heterocyclic compounds and as substrates for drug synthesis. Several 3-formylchromone derivatives possess a broad range of biological and pharmacological properties. The α-amino phosphonate derivatives constitute an important class of organophosphorus compounds on account of their versatile biological activity. Considering the importance of the three pharmacophores, promoted us to club all pharmacophores in a single molecule using green protocol. The Principles of Green chemistry are followed while performing the synthesis.

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"Green Synthesis and Docking Studies of Novel Coupled chromonyl thiadiazolyl Derivatives by Kabachnik - Fields reaction", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.7, Issue 12, page no.915 - 929, December-2022, Available :https://ijsdr.org/papers/IJSDR2212143.pdf

Volume 7 Issue 12, December-2022

Pages : 915 - 929

Paper Reg. ID: IJSDR_203215

Published Paper Id: IJSDR2212143

Downloads: 000347244

Research Area: Pharmacy

Country: AURANGABAD, MAHARASHTRa, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2212143

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2212143

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition