EVALUATION OF IMMUNOMODULATORY POTENTIAL OF PHYLLANTHUS EMBLICA FRUIT EXTRACT IN WISTAR RATS

S. ANITHA KUMARI , P. MADHUSUDHANA CHARY

Phyllanthus emblica, Rats, Immunomodulatory, humoral immunity, cell-mediated immunity

In the present study, the aqueous fruit extract of Phyllanthus emblica was evaluated for its immunomodulatory effect on the male wistar rats. The rats were divided into three groups. The first group received normal saline and served as control whereas the groups II and III received aqueous fruit extract of Phyllanthus emblica at a dose of 100 and 200mg/kg body weight/day respectively for 21 days. A significant increase was observed in the total leucocyte count, lymphocyte %, serum total protein, serum globulin and serum albumin in the treated rats in a dose-dependent manner when compared to the control rats. The treated group also exhibited an increase in the relative weight of the spleen. Further, Phyllanthus emblica treated rats (group II and III) also showed significant antibody titre values and DTPH reaction when compared to the control group thus indicating its ability to stimulate the humoral as well as cell mediated immunity.

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"EVALUATION OF IMMUNOMODULATORY POTENTIAL OF PHYLLANTHUS EMBLICA FRUIT EXTRACT IN WISTAR RATS", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.7, Issue 12, page no.1154 - 1158, December-2022, Available :https://ijsdr.org/papers/IJSDR2212186.pdf

Volume 7 Issue 12, December-2022

Pages : 1154 - 1158

Paper Reg. ID: IJSDR_203189

Published Paper Id: IJSDR2212186

Downloads: 000347332

Research Area: Engineering

Country: -, -, -

Published Paper PDF: https://ijsdr.org/papers/IJSDR2212186

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2212186

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

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