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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | SYNERGISTIC HEPATOPROTECTIVE ACTIVITY OF CHRYSIN AND CURCUMIN AGAINST LIVER FIBROSIS |
| Authors Name: | Meena Bandiya , Dr. Dharmesh Sisodiya , Dr. Kamlesh Dhashora , Pushpendra Ahirwar |
| Unique Id: | IJSDR2301141 |
| Published In: | Volume 8 Issue 1, January-2023 |
| Abstract: | Curcumin and chrysin Oxidative stress has been considered a key causing factor of liver damage induced by a variety of agents, including alcohol, drugs, viral infections, environmental pollutants, and dietary components, which in turn results in the progression of liver injury, non-alcoholic steatohepatitis, non-alcoholic liver disease, liver fibrosis, and cirrhosis. Curcumin is one of the most commonly used indigenous molecules endowed with various shielding functionalities that protect the liver. The aim of the present study is to curcumin and chrysene against synergistic pharmacological effects and molecular mechanisms, as well as clinical evidence, of curcumin as a lead compound in the prevention and treatment of oxidative associated liver diseases. “hepatoprotective or hepatotoxicity or liver” along with “oxidative or oxidant.” Results showed that curcumin exerts remarkable protective and therapeutic effects on oxidative-associated liver diseases through various cellular and molecular mechanisms. Those mechanisms include suppressing the proinflammatory cytokines, lipid peroxidation products, PI3K/Akt, and hepatic stellate cells activation, as well as ameliorating cellular responses to oxidative stress such as the expression of Nrf2, SOD, CAT, GSH, GPx, and GR. Taking together, curcumin itself acts as a free radical scavenger over the activity of different kinds of ROS via its phenolic, β-diketone, and methoxy group. Further clinical studies are still needed to recognize curcumin's structure-activity relationships and molecular mechanisms in oxidative-associated liver diseases. |
| Keywords: | curcumin, chrysene, hepatotoxicity, liver fibrosis, natural product |
| Cite Article: | "SYNERGISTIC HEPATOPROTECTIVE ACTIVITY OF CHRYSIN AND CURCUMIN AGAINST LIVER FIBROSIS", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 1, page no.882 - 891, January-2023, Available :http://www.ijsdr.org/papers/IJSDR2301141.pdf |
| Downloads: | 000337068 |
| Publication Details: | Published Paper ID: IJSDR2301141 Registration ID:203670 Published In: Volume 8 Issue 1, January-2023 DOI (Digital Object Identifier): Page No: 882 - 891 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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