5-HYDROXY PYRAZOLE DERIVATIVE AS AN ANTIHYPERLIPIDEMIC AGENT: DESIGN, SYNTHESIS AND EVALUATION WITH NPC1L1 INHIBITORY ACTIVITY

Radhika Kasera , Dr. Neha Kawathekar

Antihyperlipidemia, 5-hydroxy pyrazole, Docking, NPC1L1, Cholesterol absorption inhibitor.

In order to investigate the SAR of 5-hydroxy pyrazole analogs for the cholesterol absorption inhibitors, electron- donating group were introduced to the C-(4) carbon chain of the 5-hydroxy pyrazole derivative. Nine new derivatives of the 5- hydroxy pyrazole for the cholesterol absorption inhibitor have been synthesized. All the synthesized new compounds were evaluated for the activity to inhibit cholesterol absorption in hamster and above all of them some showed comparable good effects in suppressing the level of total cholesterol in the blood.

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"5-HYDROXY PYRAZOLE DERIVATIVE AS AN ANTIHYPERLIPIDEMIC AGENT: DESIGN, SYNTHESIS AND EVALUATION WITH NPC1L1 INHIBITORY ACTIVITY", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.8, Issue 3, page no.674 - 682, March-2023, Available :https://ijsdr.org/papers/IJSDR2303109.pdf

Volume 8 Issue 3, March-2023

Pages : 674 - 682

Paper Reg. ID: IJSDR_204493

Published Paper Id: IJSDR2303109

Downloads: 000347232

Research Area: Pharmacy

Country: Indore, MADHYA PRADESH, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2303109

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2303109

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

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