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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | A Review on Formulation and Evaluation of microspheres of cyclobenzaprine HCl- Skeleton muscle relaxant |
| Authors Name: | Saurav Sharma |
| Unique Id: | IJSDR2305007 |
| Published In: | Volume 8 Issue 5, May-2023 |
| Abstract: | The microsphere has free-flowing powder properties and contains proteins as well as synthetic or natural polymers. This polymer seems to be biodegradable in nature and particles having below 200 µm. Cyclobenzaprine hydrochloride is a sympathomimetic muscle relaxant that has been widely used for the relief of muscle spasms associated with acute, painful musculoskeletal conditions for the past 30 years. It activates the locus cerelus in the brain stem leading to an increased release of nor epinephrine in the ventral horn of the spinal cord & subsequent inhibitory action of nor epinephrine on alpha motor neurons. Cyclobenzaprine related to the first-generation Tricyclic antidepressants. Such Tricyclics including amitriptyline act to inhibit the uptake of nor epinephrine, resulting in increased trans synaptic or epinephrine concentration. They have been shown to exert analgesic effect in chronic nerve & muscle pain. The current goal of this review is to investigate multiple elements of the microparticulate drug-delivery system, such as formulation methods, evaluation, and characterization. |
| Keywords: | Microspheres, Cyclobenzaprine hydrochloride, polymer, solvent evaporation, muscle relaxants, evaluation |
| Cite Article: | "A Review on Formulation and Evaluation of microspheres of cyclobenzaprine HCl- Skeleton muscle relaxant", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 5, page no.51 - 56, May-2023, Available :http://www.ijsdr.org/papers/IJSDR2305007.pdf |
| Downloads: | 000337074 |
| Publication Details: | Published Paper ID: IJSDR2305007 Registration ID:205974 Published In: Volume 8 Issue 5, May-2023 DOI (Digital Object Identifier): Page No: 51 - 56 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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