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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Formulation And Evaluation Of Floating Tablets |
| Authors Name: | Pranav Dilip Kolte , Dr.Prasik B. Dudhe , Dr. Kailash R. Biyani , Dr. S. C. Kale |
| Unique Id: | IJSDR2305254 |
| Published In: | Volume 8 Issue 5, May-2023 |
| Abstract: | The drug delivery system aims to provide a therapeutic amount of drug to the desired site in the body and maintain the desired plasma concentration of the drug for a particular period of time. Lamivudine, an anti-viral drug, choice in the treatment of HIV has been chosen as a model drug in the formulation of controlled drug delivery systems for the present work. Various studies reported the absolute bioavailability of Lamivudine (86%) when administrate orally with a half-life of 4-6 hrs. A microparticulate floating drug delivery system was planned for Lamivudine as such a system release for a prolonged period of time and the drug would be available in the dissolved form. This would lead to improvement in the bioavailability of the drug. In this way, it stands an advantage over conventional dosage forms. Floating tablet formulations were prepared using HPMCK4M and Xanthan Gum. The prepared floating tables were characterized by their pre- and post-compression parameters. Almost all the formulations showed fairly acceptable values for all the parameters evaluated. Further, the analysis of the release mechanism was carried out by fitting the drug diffusion data to various kinetic equations. The overall curve fitting into various mathematical models was found to be average and best fitted into the zero-order kinetic model. A stability study was conducted for the prepared batch of F4-selected formulations for 60 days. There was no significant change in the drug entrapment and in-vitro release study of the floating tablet. |
| Keywords: | Antiviral, Floating tablet, Lamivudine |
| Cite Article: | "Formulation And Evaluation Of Floating Tablets", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 5, page no.1613 - 1617, May-2023, Available :http://www.ijsdr.org/papers/IJSDR2305254.pdf |
| Downloads: | 000337071 |
| Publication Details: | Published Paper ID: IJSDR2305254 Registration ID:206538 Published In: Volume 8 Issue 5, May-2023 DOI (Digital Object Identifier): Page No: 1613 - 1617 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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