Synthesis characterization and antimicrobial evaluation of indole based heterocyclic compounds

Kalyani Shashikant Bokde , Mehta Parulben D

Indole, antimicrobial, thiadiazole, cup and plate, minimum inhibitory concentration

In the present work a few 2-phenylindole derivatives were synthesized and conjugated with thiadiazole nucleus via a linker and the compounds were assessed for their antimicrobial potential. The IR spectra of all the compounds exhibited the stretching vibration peaks due to C-N, C=C, C-H Ar, CH aliphatic at 1300-1100 cm-1, 1500-1700 cm-1, 3000-3200 cm-1 and 2600-3000 cm-1 respectively. The other vibrations that appeared in the spectra included those from C-O (1000-1100 cm-1), O-H (3200-3500 cm-1) and N-O (1400-1500 cm-1). The 1HNMR spectra obtained displayed the peaks of aliphatic CH and aromatic CH as well as peak of O-H in the corresponding compounds (4b, 4c). The mass spectra displayed the molecular ion peak and the isotopic peaks as calculated. The antimicrobial action of the synthesized compounds was testing using two bacteria, Escherichia coli and staphylococcus aureus. The standard drug norfloxacin and the test compounds 4e and 4a were found to significantly inhibit the growth of the microbes in culture medium presenting IC50 value of 66.94 µg/mL for E. coli and 62.21 µg/mL for S. aureus (4e) and 78.03 µg/mL for E. coli and 107.33 µg/mL for S. aureus (4a)

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"Synthesis characterization and antimicrobial evaluation of indole based heterocyclic compounds", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.9, Issue 2, page no.284 - 290, February-2024, Available :https://ijsdr.org/papers/IJSDR2402040.pdf

Volume 9 Issue 2, February-2024

Pages : 284 - 290

Paper Reg. ID: IJSDR_209982

Published Paper Id: IJSDR2402040

Downloads: 000347288

Research Area: Pharmacy

Country: Bhopal, Madhya Pradesh, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2402040

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2402040

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

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