Crispr/cas9 mRNA Therapy gene mutation SRD5A3 in Hepato-cellular carcinoma

Sengthong MOUNPHOUMI , Phonesouda Souphamith , Viengsavanh KHAMMOUNHEUANG , Douangphrachan SATHATHONE , Phetsamay PHOMMASENG

CRISPR/Cas9, Liver cancer, proliferation, cycle, invasion.

A primary hepatocellular carcinoma (HCC, liver cancer for short) is a common malignant tumor that seriously threatens human life and health. It is the sixth most common malignant tumor in humans and ranks third in the global cause of cancer-related deaths. However, the relationship between the expression of SRD5A3 and platinum-based chemotherapy resistance of liver cancer remains to be further explored. Whether the inhibition of centrosome-associated protein SRD5A3 kinase gene by small interfering RNA can inhibit the occurrence and development of hepatocellular carcinoma, the effect of SRD5A3 on the biological behavior of liver cancer cells has not been reported at home and abroad. If the changes in SRD5A3 can be used to guide the diagnosis and treatment of hepatocellular carcinoma and evaluate the prognosis of patients, the related research of SRD5A3 will play a major role in the diagnosis and treatment of hepatocellular carcinoma. These researches use CRISPR/Cas9 (Clustered Regularly Inter Spaced Short Pali

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"Crispr/cas9 mRNA Therapy gene mutation SRD5A3 in Hepato-cellular carcinoma", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.9, Issue 9, page no.218 - 232, September-2024, Available :https://ijsdr.org/papers/IJSDR2409023.pdf

Volume 9 Issue 9, September-2024

Pages : 218 - 232

Paper Reg. ID: IJSDR_212447

Published Paper Id: IJSDR2409023

Downloads: 000347272

Research Area: Health Science 

Country: Vientiane, Vientiane Capital, Lao People's Democratic Republic

Published Paper PDF: https://ijsdr.org/papers/IJSDR2409023

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2409023

DOI: https://doi.org/10.5281/zenodo.13823374

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition