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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Therapeutic antibodies and its use in COVID-19: a review |
| Authors Name: | P U Monica , Tera Sony |
| Unique Id: | IJSDR2307031 |
| Published In: | Volume 8 Issue 7, July-2023 |
| Abstract: | Proteins, Peptides, Monoclonal antibodies, gene therapy, cell therapy and RNAi (RNA Interference) come under large therapeutic molecules. These are progressively represented as new molecular entities registered through the FDA (Food and Drug Administration). The majority of NME’s (New Molecular Entities) registered to date, are still small molecules. Under antibody-therapeutics, since 2019, in clinical trials over 82 antibody- NMEs (New Molecular Entities) have been approved to treat diseases with hundreds more. The development of antibody-based bio-pharmaceutics for effective and safe treatment of many diseases like autoimmune, oncology, transplantation and inflammatory disorders has shown noteworthy success in the last three decades. Development and significant rapid growth leading to clinical success began in the 1990s. Over 80 regulatory approvals have demonstrated this fact. Since 2015, it is estimated that more than 100 therapeutic antibodies, such as monoclonal antibodies ( mAbs), have entered first-in-human (FIH) studies per year and 700 antibody-based therapeutics are currently in some stage of clinical development. |
| Keywords: | Monoclonal antibodies, Immunoglobulin G, Hybridoma technology, Covid-19, Cancer treatment |
| Cite Article: | "Therapeutic antibodies and its use in COVID-19: a review", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 7, page no.233 - 240, July-2023, Available :http://www.ijsdr.org/papers/IJSDR2307031.pdf |
| Downloads: | 000338719 |
| Publication Details: | Published Paper ID: IJSDR2307031 Registration ID:207589 Published In: Volume 8 Issue 7, July-2023 DOI (Digital Object Identifier): Page No: 233 - 240 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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