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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | DEVELOPMENT AND VALIDATION OF UV SPECTROSCOPIC METHOD FOR SIMULTANEOUS ESTIMATION OF FLUTICASONE FUROATE AND VILANTEROL IN PHARMACEUTICAL FORMULATIONS |
| Authors Name: | Ashwini Pawar , Sagar Kale , Sanket Patil , Kaufiya Sayyad , Ranjeet Vibhute |
| Unique Id: | IJSDR2307201 |
| Published In: | Volume 8 Issue 7, July-2023 |
| Abstract: | The present study describes a new, simple, precise, accurate, reproducible, and efficient UV spectroscopic method that was developed and validated for simultaneous estimation of fluticasone furoate and Vilanterol in pure and pharmaceutical dosage form. The absorbance of fluticasone furoate and Vilanterol was found to be 242nm and 259nm, respectively. Calibration curves of fluticasone furoate and Vilanterol were found to be linear in the concentration ranges of 8-12µg/mL and 2-3µg/mL with their correlation coefficient values (R2) 0.9987 and 0.9992, respectively. LOD and LOQ were found to be 0.68µg/mL and 2.07µg/mL for Fluticasone Furoate and 0.13µg/mL and 0.40µg/mL for Vilanterol, respectively. In the precision study, the % RSD value was found within limits (RSD < 2%). The percentage recovery at various concentration levels varied from 99.73 to 100.60% for Fluticasone Furoate and 101.80 to 100.66% for Vilanterol, respectively. The proposed method can be applied successfully for the simultaneous estimation of fluticasone furoate and Vilanterol in pure and pharmaceutical dosage form. In this method simultaneous equation method was applied to find assay of both drugs in pharmaceutical dosage form. The methods were validated in accordance with ICH Q2 guidelines. |
| Keywords: | Fluticasone furoate, Vilanterol, UV-visible Spectrometry |
| Cite Article: | "DEVELOPMENT AND VALIDATION OF UV SPECTROSCOPIC METHOD FOR SIMULTANEOUS ESTIMATION OF FLUTICASONE FUROATE AND VILANTEROL IN PHARMACEUTICAL FORMULATIONS", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 7, page no.1337 - 1345, July-2023, Available :http://www.ijsdr.org/papers/IJSDR2307201.pdf |
| Downloads: | 000338719 |
| Publication Details: | Published Paper ID: IJSDR2307201 Registration ID:208029 Published In: Volume 8 Issue 7, July-2023 DOI (Digital Object Identifier): Page No: 1337 - 1345 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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