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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | CBNAAT as a tool for revolutionizing the Diagnosis of Tuberculous Meningitis in Adults: Insights from a Tertiary Care Hospital in Northern India |
| Authors Name: | Dr Pratiksha Kamboj , Dr Yogendra Pratap Mathuria , Dr Deepika Chakraborty , Dr Pratima Gupta , Dr Priyal Anand |
| Unique Id: | IJSDR2308011 |
| Published In: | Volume 8 Issue 8, August-2023 |
| Abstract: | Introduction: Tuberculous meningitis (TBM) remains a challenging and potentially fatal form of extrapulmonary tuberculosis. The conventional methods for TBM diagnosis, such as microscopy and culture, have limitations in terms of sensitivity and speed. The Cartridge-Based Nucleic Acid Amplification Test (CBNAAT) offers a rapid and reliable diagnostic approach for Mycobacterium tuberculosis detection and rifampicin resistance. This study aimed to evaluate the diagnostic usefulness of CBNAAT in diagnosing TBM in adults at a tertiary care hospital in Northern India. Methodology: This study was carried out at the Department of Microbiology, AIIMS, Rishikesh from January 2019 to March 2022. A total of 132 patients admitted with suspicion of tuberculous meningitis in our hospital during the study period were included in this study. Cerebrospinal fluid (CSF) samples were collected from patients and subjected to tests for Zeihl-Neelsen (ZN) staining, CBNAAT and culture. Results: CBNAAT identified MTB in 63/128 samples from the patients (49.2%). In relation to composite reference standards, the CBNAAT's sensitivity, specificity, positive predictive value, and negative predictive value are 98.4%, 100%, 100%, and 98.5%, respectively. Among the 63 instances that CBNAAT identified, 7 incidences of rifampicin resistance were additionally identified (11.11%). A strong statistically significant agreement was observed with CBNAAT. |
| Keywords: | TBM, CBNAAT, ZN Smear |
| Cite Article: | "CBNAAT as a tool for revolutionizing the Diagnosis of Tuberculous Meningitis in Adults: Insights from a Tertiary Care Hospital in Northern India", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 8, page no.68 - 73, August-2023, Available :http://www.ijsdr.org/papers/IJSDR2308011.pdf |
| Downloads: | 000338719 |
| Publication Details: | Published Paper ID: IJSDR2308011 Registration ID:207189 Published In: Volume 8 Issue 8, August-2023 DOI (Digital Object Identifier): Page No: 68 - 73 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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