INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15
FORMULATION AND CHARACTERIZATION OF SILVER NANOPARTICLES AND ASSESSMENT OF THEIR MEDICINAL APPLICATION
Authors Name:
Miss Komal Shahu
, Mr.Tushar P. Akhare , Dr. Lahu D Hingane , Prof. Mahesh Mhaske
Unique Id:
IJSDR2308057
Published In:
Volume 8 Issue 8, August-2023
Abstract:
The aim of the present study is to formulate and evaluate antibacterial drug loaded silver nanoparticles for synergistic activity. It involves formulate and evaluate silver nanoparticles, Conjugation of silver nanoparticles with some antibacterial drugs and increase the drug antibacterial activity by Nano sizing the drug particles. To reduce the dose of the drug and eventually the adverse side effects. To increase the activity of antibacterial drug against different microorganism. To study the in-vitro diffusion study of optimized formulation. To find out the effect of antibacterial drug loaded silver nanoparticles on different bacterial culture by using animal model. Further evaluation and characterization of these batches of nanoparticles for the particle size, Polydispersity index, zeta potential & % entrapment efficiency. The results observed for particle size AgNPs were found to be below 100 nm. The zeta potential of batch was found in range of –6.80± 1.50 mV. Typically a minimum zeta potential of greater than -30 mV is considered acceptable and indicative of good stability.. optimized batches were used to perform the antimicrobial activity of silver nanoparticles were observed with increased effect than single drug Minimum inhibitory concentration and bacterial sensitivity of drug with synergistic activity were determined by using well diffusion method. In which Silver nanoparticles showed the MIC at concentration of 0.003% respectively.
"FORMULATION AND CHARACTERIZATION OF SILVER NANOPARTICLES AND ASSESSMENT OF THEIR MEDICINAL APPLICATION", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 8, page no.409 - 413, August-2023, Available :http://www.ijsdr.org/papers/IJSDR2308057.pdf
Downloads:
000338720
Publication Details:
Published Paper ID: IJSDR2308057
Registration ID:208189
Published In: Volume 8 Issue 8, August-2023
DOI (Digital Object Identifier):
Page No: 409 - 413
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631
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