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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Carcinomatous Meningitis, A Rare Etiology Of Rapidly Progressive Dementia |
| Authors Name: | Mouhouche Imed , Kediha M.I , Ali pacha L |
| Unique Id: | IJSDR2308104 |
| Published In: | Volume 8 Issue 8, August-2023 |
| Abstract: | Most dementias often develop slowly and progressively, but in some cases we are faced with presentations whose worsening is very rapid. The neoplastic origin of a rapidly progressive dementia is rare, its occurrence is related to a spread of the tumor to the meninges and cerebrospinal fluid (CSF).This article presents the clinical case of a 75-year-old man with multiple comorbidities and a small cell bronchial adenocarcinoma under treatment, which presents a rapidly progressive cognitive decline over a few weeks and progressing to aggravation. The neurological examination did not find any signs of focusing and the neuropsychological tests show a severe alteration of the memory and executive cognitive functions. Cerebral MRI reveals stage 3 medial temporal atrophy, a diffuse cortico-subcortical atrophy associated and a few demyelinating lesions with a degenerative appearance. Infectious, deficiency, autoimmunity and thyroid tests were carried out and returned without abnormality. The search for anti-neuronal antibodies is negative. Cytological analysis of the cerebrospinal fluid (CSF) showed a sheet of blastoid cells of medium to large hetero size with the presence of a few images of mitosis. Based on the”medical” history “of the patient” and the results of CSF cytology, the diagnosis of carcinomatous meningitis secondary to metastatic lung cancer is retained. Our case underlines the importance of the study of CSF, especially cytology in patients with an atypical dementia in search of tumor cells. |
| Keywords: | Carcinomatous meningitis, rapidly progressive dementia, neoplasia, CSF |
| Cite Article: | "Carcinomatous Meningitis, A Rare Etiology Of Rapidly Progressive Dementia", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 8, page no.717 - 720, August-2023, Available :http://www.ijsdr.org/papers/IJSDR2308104.pdf |
| Downloads: | 000338720 |
| Publication Details: | Published Paper ID: IJSDR2308104 Registration ID:207960 Published In: Volume 8 Issue 8, August-2023 DOI (Digital Object Identifier): Page No: 717 - 720 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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