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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Pharmacognostical Studies and Pharmacological Investigations for Anti-diabetic Activities of Taraxacum officinale Weber (Dandelion) |
| Authors Name: | Mohd Zafar , Dr. Bhanu P. S. Sagar , Dr. Amrita Singh , Snehil Singh , Abdul Hafeez |
| Unique Id: | IJSDR2308119 |
| Published In: | Volume 8 Issue 8, August-2023 |
| Abstract: | Taraxacum officinale (dandelion) contains active pharmaceutical agents with various medicinal activities. This research work was an attempt to establish scientific protocols to perform pharmacological investigation / research on Taraxacum officinale for antidiabetic effect against STZ induced diabetes in rats. Plant parts were analysed pharmacognostically and authenticated showed the presence of resin, glycosides, phenolic compounds, flavanoids, steroids, and amino acids. High total phenolic content and total flavonoid content were found in the EETOL extract then EETOR extract. In-vivo pharmacological investigation for anti-diabetic activity of EETOL / EETOR against streptozotocin induced diabetes was performed and it was found that both EETOL-B extract and EETOL-A extracts produced significant anti-diabetic effects. EETOL-B extract lowered the blood glucose level, LDL and VLDL significantly and produced better action than EETOL-A. Anti-diabetic potential was comparable with glipizide (Standard drug). Extract EETOL-B repaired beta cells, revitalized damaged cells, extracts rejuvenates cells and induce insulin secretion. Finally, much more elaborated pharmacological research is recommended. |
| Keywords: | Anti-diabetic, dandelion, glipizide, lipoproteins, Oral glucose tolerance test, quercetin, total phenolic content, total flavonoid content, streptozotocin. |
| Cite Article: | "Pharmacognostical Studies and Pharmacological Investigations for Anti-diabetic Activities of Taraxacum officinale Weber (Dandelion) ", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 8, page no.807 - 817, August-2023, Available :http://www.ijsdr.org/papers/IJSDR2308119.pdf |
| Downloads: | 000338719 |
| Publication Details: | Published Paper ID: IJSDR2308119 Registration ID:208295 Published In: Volume 8 Issue 8, August-2023 DOI (Digital Object Identifier): Page No: 807 - 817 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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