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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Development and Validation of HPTLC Method for the Simultaneous Estimation of Loteprednol Etabonate in Drug Dosage Form. |
| Authors Name: | Souravh Jha , Arti Rai , Pinky Singh , Mithun Verma , Dr V.P Gupta |
| Unique Id: | IJSDR2309131 |
| Published In: | Volume 8 Issue 9, September-2023 |
| Abstract: | ABSTRACT A simple, accurate, precise high-performance thin-layer chromatographic method for simultaneous estimation of Loteprednol etabonate LE in ophthalmic formulation has been developed and validated. The method employed TLC aluminium plates precoated with silica gel 60F254 as stationary phase. The solvent system consisted of methanol: ethylacetate: triethylamine (7:3:0.2v/v/v). Densitometric analysis was carried out at 272nm for LE. The system was found to give compact spots for LE at Rf value of 0.70 respectively. The linear regression analysis data showed a good linear relationship in the concentration range of 1-5µg/spot for LE. The % recovery was found to be 99-102% for LE. The correlation coefficient was found to be 0.999 for LE. The % RSD values indicated that the proposed method was precise. The specificity of the method was ascertained by peak purity profiling studies and the developed method was specific. The method has been successfully applied in the analysis of combined dosage form. |
| Keywords: | Keywords: Loteprednol etabonate, HPTLC and Method Validation. |
| Cite Article: | "Development and Validation of HPTLC Method for the Simultaneous Estimation of Loteprednol Etabonate in Drug Dosage Form.", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 9, page no.912 - 914, September-2023, Available :http://www.ijsdr.org/papers/IJSDR2309131.pdf |
| Downloads: | 000338720 |
| Publication Details: | Published Paper ID: IJSDR2309131 Registration ID:208679 Published In: Volume 8 Issue 9, September-2023 DOI (Digital Object Identifier): Page No: 912 - 914 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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