|
INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
Imp Links for Author
Imp Links for Reviewer
Research Area
Subscribe IJSDR
Visitor Counter
Copyright Infringement Claims
Indexing Partner
|
Published Paper Details
|
|
| Paper Title: | Effects of drug policy changes on the evolution of Pfmdr1 and Pfcrt resistance molecular markers of Plasmodium falciparum to chloroquine in Bangui, Central African Republic |
| Authors Name: | Ngum Lesley Ngum , Jean Paul Kengne Chedjou, Calvino Tah Fomboh , Diman-Ronsone André, Aristid M Ekollo , Akindeh M Nji, Palmer Masumbe Netongo , Wilfred F Mbacham, Mbu’u Mbanwi Cyrille |
| Unique Id: | IJSDR2310010 |
| Published In: | Volume 8 Issue 10, October-2023 |
| Abstract: | Abstract Malaria remains one of the main threats to public health. The emergence of drug resistance is a major obstacle to the fight against malaria. Due to the spread of parasites resistant to antimalarial drugs, treatment guidelines for malaria in the Central African Republic have evolved from monotherapy to artemisinin-based combination therapy. Prediction of decrease or increase in antimalarial susceptibility and fixation of multidrug resistance genotypes is essential in the fight against malaria. To assess the impact of drug policy, we examined molecular changes in the chloroquine-associated Pfcrt and Pfmdr1 resistance marker to monitor the evolution of mutant alleles since the withdrawal of chloroquine from the market following the adoption of Artemisinin based Combined Therapies (ACT) in the Central African Republic. To assess the evolution of these markers, dried blood spots were prepared from 138 children diagnosed positive for plasmodium falciparum malaria by rapid diagnostic test. DNA was then extracted from the blood and genotyped. The chi-square test was used to check for the association between the period of withdrawal and the time of sample analysis. The alleles conferring resistance to chloroquine in the Pfmdr1-86Y genotype showed a significant increase from 1.72% in 2010 to 99.1% in 2021, on the other hand, they was a reduction in the mutant alleles Pfcrt-76T and an increase in mixed infection from 0% in 2010 to 3.48% in 2021 (P<0.05). The results demonstrated a clear increase in the pfmdr1 resistant marker. |
| Keywords: | Key words; Plasmodium, Chloroquine, molecular markers, policy |
| Cite Article: | "Effects of drug policy changes on the evolution of Pfmdr1 and Pfcrt resistance molecular markers of Plasmodium falciparum to chloroquine in Bangui, Central African Republic ", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 10, page no.48 - 52, October-2023, Available :http://www.ijsdr.org/papers/IJSDR2310010.pdf |
| Downloads: | 000338719 |
| Publication Details: | Published Paper ID: IJSDR2310010 Registration ID:208412 Published In: Volume 8 Issue 10, October-2023 DOI (Digital Object Identifier): https://doi.org/10.5281/zenodo.10148921 Page No: 48 - 52 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
|
Click Here to Download This Article |
|
| Article Preview | |
|
|
|
Major Indexing from www.ijsdr.org
| Google Scholar | ResearcherID Thomson Reuters | Mendeley : reference manager | Academia.edu |
| arXiv.org : cornell university library | Research Gate | CiteSeerX | DOAJ : Directory of Open Access Journals |
| DRJI | Index Copernicus International | Scribd | DocStoc |
Track Paper
Important Links
Conference Proposal
ISSN
 |
 |
DOI (A digital object identifier)
  Providing A digital object identifier by DOI How to GET DOI and Hard Copy Related |
Open Access License Policy
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
|
 |
 |
 |
Social Media
Indexing Partner |
|||
| Copyright © 2024 - All Rights Reserved - IJSDR | |||
Facebook Twitter Instagram LinkedIn