|
INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
Imp Links for Author
Imp Links for Reviewer
Research Area
Subscribe IJSDR
Visitor Counter
Copyright Infringement Claims
Indexing Partner
|
Published Paper Details
|
|
| Paper Title: | Formulation Development and Evaluation of Microspheres of Cefpodoxime Proxetil - A Broad Spectrum Cephalosporin with Short Half-life |
| Authors Name: | Shivani Mishra , Raj Kumar Mishra , Fabiha Rahish , Bhanu P. S. Sagar |
| Unique Id: | IJSDR2310114 |
| Published In: | Volume 8 Issue 10, October-2023 |
| Abstract: | In present investigation, to develop mucoadhesive microsphere of cefpodoxime proxetil, it was first identified by characteristics infrared spectra and then it was subjected to melting point determination, partition coefficient determination and solubility analysis. After that the drug was analysed in UV spectrophotometer by constructing standard curve in 0.1 N HCl (pH-1.2). It was found that the drug was confirming all the pharmacopoeial standards with respect to melting point, partition coefficient, solubility, wavelength of maximum absorption (λmax) and the characteristics of IR spectra. Polymer used in formulation of microspheres, may interfere in the estimation of drug. The mp of cefpodoxime proxetil was found to be 1110C. The PC of cefpodoxime proxetil was found to be 5.1 (lipophilic). Formulations FC2 and FC4 follows zero order release kinetics with r2 value of 0.991, 0.998 respectively. From the study it is evident that promising controlled release mucoadhesive microspheres of cefpodoxime proxetil may be developed by solvent evaporation techniques by using polymers for reduced dosing frequency and better patient compliance therapy. |
| Keywords: | Bioadhesive, drug release, gastrointestinal tract, melting point determination, microspheres, lipophilic, partition coefficient, polymers, solubility. |
| Cite Article: | "Formulation Development and Evaluation of Microspheres of Cefpodoxime Proxetil - A Broad Spectrum Cephalosporin with Short Half-life", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 10, page no.718 - 739, October-2023, Available :http://www.ijsdr.org/papers/IJSDR2310114.pdf |
| Downloads: | 000338720 |
| Publication Details: | Published Paper ID: IJSDR2310114 Registration ID:208713 Published In: Volume 8 Issue 10, October-2023 DOI (Digital Object Identifier): Page No: 718 - 739 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
|
Click Here to Download This Article |
|
| Article Preview | |
|
|
|
Major Indexing from www.ijsdr.org
| Google Scholar | ResearcherID Thomson Reuters | Mendeley : reference manager | Academia.edu |
| arXiv.org : cornell university library | Research Gate | CiteSeerX | DOAJ : Directory of Open Access Journals |
| DRJI | Index Copernicus International | Scribd | DocStoc |
Track Paper
Important Links
Conference Proposal
ISSN
 |
 |
DOI (A digital object identifier)
  Providing A digital object identifier by DOI How to GET DOI and Hard Copy Related |
Open Access License Policy
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
|
 |
 |
 |
Social Media
Indexing Partner |
|||
| Copyright © 2024 - All Rights Reserved - IJSDR | |||
Facebook Twitter Instagram LinkedIn