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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Formulation and Evaluation of Amphiphilogels of Piroxicam for Enhancement of its Transdermal Drug Delivery |
| Authors Name: | Fabiha Rahish , Raj Kumar Mishra , Shivani Mishra , Bhanu P. S. Sagar |
| Unique Id: | IJSDR2310115 |
| Published In: | Volume 8 Issue 10, October-2023 |
| Abstract: | Piroxicam has very low permeation across skin layers due to its hydrophobicity. Amphiphilogel is a semisolid system serve as a better vehicle for this “Difficult drug”. The preformulation studies were done as a means for identification of drug and gelators. Compatibility studies were done on the basis of FTIR. Solubility and partition co-efficient was measured in different solvents. Tween 80 was proved better over span 80 as a solvent. Amphiphilogels were prepared by weighing span 40 [(3% w/w), (solid gelator)]. Two groups were prepared naming as hydrophilic amphiphilogels and lypophilic amphiphilogels. The samples were found to be pale yellow in color with a minute difference in hydrophilic and lypophilic formulations. On increasing gelator concentration clusters rose in number. All formulations were easily washable and have good spredability. Piroxicam showed greater release from hydrophilic amphiphilogels as compared to lypophilic amphiphilogels. Amongst the hydrophilic amphiphilogels HF4 showed the highest permeation containing ethanol as a co-solvent followed by HF1> HF2 > HF3. Zero order as well as korsmeyer peppas kinetic model both were obeyed by all amphiphilogel formulations. Transdermal flux value were calculated from the slope which suggested that the value of transdermal flux was highest in HF4 contains ethanol as penetration enhancer. All the formulation showed increased transdermal flux then HF0 containing no penetration enhancer. Transdermal flux of hydrophilic amphiphilogels was higher than lypophilic amphiphilogels. All amphiphilogels came to gel state when the temperature was reduced to 40C, indicating their thermoreversibility. |
| Keywords: | Amphiphilogels, gelator, hydrophilic, lypophilic, partition co-efficient, penetration enhancer, transdermal flux, thermoreversibility |
| Cite Article: | "Formulation and Evaluation of Amphiphilogels of Piroxicam for Enhancement of its Transdermal Drug Delivery", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 10, page no.740 - 757, October-2023, Available :http://www.ijsdr.org/papers/IJSDR2310115.pdf |
| Downloads: | 000338720 |
| Publication Details: | Published Paper ID: IJSDR2310115 Registration ID:208714 Published In: Volume 8 Issue 10, October-2023 DOI (Digital Object Identifier): Page No: 740 - 757 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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