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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Formulation and Evaluation of Bi-layered Tablet of Divalproex Sodium |
| Authors Name: | Aditya Gupta , Dr. Nidhi Bais |
| Unique Id: | IJSDR2312059 |
| Published In: | Volume 8 Issue 12, December-2023 |
| Abstract: | The objective of the current study was to develop bi-layered tablets of Divalproex Sodium containing immediate release layer and sustained release layer. Divalproex Sodium is considered as the most important antiepileptic drug and widely used for treatment of epilepsy and bi-polar disorders and prophylaxis of migraine. Both layer of divalproex sodium were prepared by wet granulation method. The immediate release layer was formulated by using sodium starch glycolate, croscarmellose sodium as super disintegrants. HPMC K4M and HPMC K100M polymer used to retard the drug release from sustained release layer in different proportion and combination. The optimized Immediate release layer (IF6) & sustained release layer (SF6) were selected to prepare Bi-layered tablet of Divalproex Sodium. In-vitro drug release studies were performed using USP type II apparatus (paddle method) in 900 ml of phosphate buffer pH 6.8 at 100 rpm. All the formulations were evaluated for post-compression parameters like hardness, weight variation, friability, thickness, disintegration time, drug content and in-vitro % drug release. The formulations were selected based on their disintegration time and in-vitro % drug release. The final results obtained showed that the disintegration time is 35.33 seconds and in-vitro % drug release of IRL 99.50 % & in-vitro % drug release of SRL 99.56%. |
| Keywords: | Divalproex Sodium, Bi-layered Tablet, Antiepileptic, Patient acceptance, Immediate Release, Sustained Release |
| Cite Article: | "Formulation and Evaluation of Bi-layered Tablet of Divalproex Sodium ", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 12, page no.432 - 440, December-2023, Available :http://www.ijsdr.org/papers/IJSDR2312059.pdf |
| Downloads: | 000338720 |
| Publication Details: | Published Paper ID: IJSDR2312059 Registration ID:209569 Published In: Volume 8 Issue 12, December-2023 DOI (Digital Object Identifier): Page No: 432 - 440 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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