|
INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
Imp Links for Author
Imp Links for Reviewer
Research Area
Subscribe IJSDR
Visitor Counter
Copyright Infringement Claims
Indexing Partner
|
Published Paper Details
|
|
| Paper Title: | Molecular Docking Studies of Antirrhinum majus-derived Compounds for CNS Stimulant Activity: Insights into Ligand-Receptor Interactions and Potential Therapeutic Candidates |
| Authors Name: | MOHD. ZEESHAN , DR. RAKESH KUMAR GAWALY , DR. UDIT NARAYAN SONI , DR. KAVITA R, LOKSH |
| Unique Id: | IJSDR2312088 |
| Published In: | Volume 8 Issue 12, December-2023 |
| Abstract: | Antirrhinum majus, also known as snapdragon, is a medicinal plant that has a long history of traditional use for an array of therapeutic purposes. Molecular docking studies have gained significance as an indispensable tool for predicting the binding interactions between compounds and target proteins. This research employs molecular docking studies to explore the CNS stimulant activity of compounds derived from Antirrhinum majus. The investigation focuses on their interactions with the DAT receptor (PDB code: 4M48), which is known to play a significant role in CNS stimulant activity. The main objective was to investigate the binding affinities of the phytoconstituents and identify the particular amino acid residues involved in the biochemical interactions at the binding site. The top 5 hits exhibited binding affinities from -10.9 to -8.8 kcal/mol. Notably, the designed compounds demonstrated favorable biochemical interactions with the target protein, establishing strong hydrogen bonding with Arg476, Asp475, and Ala117, along with pi bonding with Tyr124 and Phe325. These findings provide critical insights into the potential of these inhibitors as promising candidates for modulating neuronal activities in the context of CNS stimulant activity. |
| Keywords: | Molecular docking, Antirrhinum majus, CNS stimulant activity, ligand-receptor interactions, neurological disorders. |
| Cite Article: | "Molecular Docking Studies of Antirrhinum majus-derived Compounds for CNS Stimulant Activity: Insights into Ligand-Receptor Interactions and Potential Therapeutic Candidates", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 12, page no.671 - 678, December-2023, Available :http://www.ijsdr.org/papers/IJSDR2312088.pdf |
| Downloads: | 000340271 |
| Publication Details: | Published Paper ID: IJSDR2312088 Registration ID:209317 Published In: Volume 8 Issue 12, December-2023 DOI (Digital Object Identifier): Page No: 671 - 678 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
|
Click Here to Download This Article |
|
| Article Preview | |
|
|
|
Major Indexing from www.ijsdr.org
| Google Scholar | ResearcherID Thomson Reuters | Mendeley : reference manager | Academia.edu |
| arXiv.org : cornell university library | Research Gate | CiteSeerX | DOAJ : Directory of Open Access Journals |
| DRJI | Index Copernicus International | Scribd | DocStoc |
Track Paper
Important Links
Conference Proposal
ISSN
 |
 |
DOI (A digital object identifier)
  Providing A digital object identifier by DOI How to GET DOI and Hard Copy Related |
Open Access License Policy
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
|
 |
 |
 |
Social Media
Indexing Partner |
|||
| Copyright © 2024 - All Rights Reserved - IJSDR | |||
Facebook Twitter Instagram LinkedIn