INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15
A Study on the effect of different doses of pregabalin on the testis in adult male albino rat.
Authors Name:
Marwa Sayed Badawi
Unique Id:
IJSDR2312113
Published In:
Volume 8 Issue 12, December-2023
Abstract:
Background: Pregabalin (PGB) is an anti-convulsant drug that is indicated in epilepsy, neuropathic pain and anxiety. Pregabalin is an analogue to the neurotransmitter gamma amino butyric acid (GABA). Its main site of action is in the peripheral and central nervous systems. The present study aimed to evaluate the effect of different doses of pregabalin on the Testis in adult male rats. Methods: 30 male albino rats were divided into 3 groups with 10 rats in each group. Group I (control group). Group ІІ animals received pregabalin orally in a dose of 600 mg/kg/day for 4 weeks. Group ІІI animals received pregabalin orally in a dose of 1200 mg/kg/day for 4 weeks. At the end of the experiment, Blood samples were taken and concentrations of testosterone, FSH and LH were measured by Radioimmunoassay method. Then, the testes were processed for histopathological study. Results: The results showed that administration of PGB at a dose of 1200 mg/kg reduced serum testosterone level while it increased FSH and LH levels (p<0.05). It also caused a decrease in sperm motility, count and percent of viability and an increase in sperm abnormalities (p<0.05). Histological examination of the testes showed reduction in the number of spermatogenic and Leydig cells. Conclusion: PGB has toxic effects on the testes when given at a dose of 1200 mg/kg as indicated by decreased concentration of testosterone, increased FSH and LH levels, a decrease in sperm motility, count and percent of viability, an increase in sperm abnormalities and reduced number of spermatogenic and leydig cells.
"A Study on the effect of different doses of pregabalin on the testis in adult male albino rat.", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.8, Issue 12, page no.860 - 867, December-2023, Available :http://www.ijsdr.org/papers/IJSDR2312113.pdf
Downloads:
000338719
Publication Details:
Published Paper ID: IJSDR2312113
Registration ID:209684
Published In: Volume 8 Issue 12, December-2023
DOI (Digital Object Identifier):
Page No: 860 - 867
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631
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