|
INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
Imp Links for Author
Imp Links for Reviewer
Research Area
Subscribe IJSDR
Visitor Counter
Copyright Infringement Claims
Indexing Partner
|
Published Paper Details
|
|
| Paper Title: | AN OVERVIEW OF NANOSUSPENSION PREPARATION, CHARACTERIZATION, AND EVALUATION AS A STRATEGY FOR POORLY SOLUBLE DRUGS |
| Authors Name: | Lavkush Santosh Jadhav , Dr. Avinash H. Hosmani , Poonam B. Mane , Divyani D. Mane , Vishnu V. Mali |
| Unique Id: | IJSDR2401037 |
| Published In: | Volume 9 Issue 1, January-2024 |
| Abstract: | Abstract :- The speed at which the drug development process is progressing is producing a number of novel drug candidates with good therapeutic efficacy but poor water solubility. Because of its unique physicochemical characteristics and submicron particle size, nanosuspension holds the potential to address numerous formulation and drug delivery challenges that are commonly linked to poorly soluble medicines in water and fat. To manufacture and scale-up nanosuspensions, conventional size reduction tools like media mills and high-pressure homogenizers as well as formulation strategies including solvent diffusion, emulsion-solvent evaporation, precipitation, and microemulsion procedures can be effectively used. For the successful manufacture and scaling-up of nanosuspensions, it is important to take into account two crucial factors: maintaining the stability in both the solid and solution states and resuspendability without aggregation. The versatility for surface modification and mucoadhesion for drug targeting, along with the notable improvement in bioavailability, have greatly broadened the application of this innovative formulation approach. Much research is now being done on the use of nanosuspensions in various drug delivery methods, including oral, ophthalmic, brain, topical, buccal, nasal, and transdermal routes. Receptor-mediated endocytosis in combination with oral drug delivery in nanosuspension has great promise for resolving most permeability-limited absorption and hepatic first-pass metabolism-related problems that negatively impact bioavailability. The development of enabling technologies, including nanosuspension, can address numerous formulation issues that currently plague protein and as well as peptide based formulation. |
| Keywords: | Nanosuspension, novel drug delivery, solubility enhancement, Surfactant. |
| Cite Article: | "AN OVERVIEW OF NANOSUSPENSION PREPARATION, CHARACTERIZATION, AND EVALUATION AS A STRATEGY FOR POORLY SOLUBLE DRUGS", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.9, Issue 1, page no.267 - 276, January-2024, Available :http://www.ijsdr.org/papers/IJSDR2401037.pdf |
| Downloads: | 000338719 |
| Publication Details: | Published Paper ID: IJSDR2401037 Registration ID:209806 Published In: Volume 9 Issue 1, January-2024 DOI (Digital Object Identifier): Page No: 267 - 276 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
|
Click Here to Download This Article |
|
| Article Preview | |
|
|
|
Major Indexing from www.ijsdr.org
| Google Scholar | ResearcherID Thomson Reuters | Mendeley : reference manager | Academia.edu |
| arXiv.org : cornell university library | Research Gate | CiteSeerX | DOAJ : Directory of Open Access Journals |
| DRJI | Index Copernicus International | Scribd | DocStoc |
Track Paper
Important Links
Conference Proposal
ISSN
 |
 |
DOI (A digital object identifier)
  Providing A digital object identifier by DOI How to GET DOI and Hard Copy Related |
Open Access License Policy
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
|
 |
 |
 |
Social Media
Indexing Partner |
|||
| Copyright © 2024 - All Rights Reserved - IJSDR | |||
Facebook Twitter Instagram LinkedIn