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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Thyroid autoimmunity role of thyroid in antibodies in thyroid and extra thyroidal diseases |
| Authors Name: | K.Malleswari , D. Rama Bramha Reddy , A. Satish |
| Unique Id: | IJSDR2402013 |
| Published In: | Volume 9 Issue 2, February-2024 |
| Abstract: | Autoimmune thyroid disease (AITD) refers to a spectrum of various diseases, with two extremes of clinical presentation, hypothyroidism (Hashimoto’s thyroiditis (HT) and hyperthyroidism (Graves–Basedow disease (GBD)). Both conditions are characterized by presenting a cellular and humoral autoimmune reaction, with an increase in the synthesis and secretion of antibodies directed toward various thyroid antigens, together with a phenomenon of thyrocyte necrosis and apoptosis (in HT) and a persistent thyrotropin-receptor stimulation (in GBD). The diagnosis of both entities is based on clinical, laboratory, and imaging findings. Three major anti-thyroid antibodies have been described, those directed against the TSH receptor (TRAb), against thyroid peroxidase (TPOAb), and against thyroglobulin (TgAb). Each of these autoantibodies plays a fundamental role in the diagnostic approach of autoimmune thyroid disease. TRAbs are the hallmark of GBD, and additionally, they are predictors of response to disease treatment, among other utilities. Likewise, TPOAb and TgAb allow for identifying individuals with a higher risk of progression to hypothyroidism; the positivity of one or both autoantibodies defines the presence of thyroid autoimmunity. In this review, the usefulness of anti-thyroid antibodies in the diagnostic approach to autoimmune thyroid disease is described. |
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| Cite Article: | "Thyroid autoimmunity role of thyroid in antibodies in thyroid and extra thyroidal diseases", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.9, Issue 2, page no.74 - 81, February-2024, Available :http://www.ijsdr.org/papers/IJSDR2402013.pdf |
| Downloads: | 000338720 |
| Publication Details: | Published Paper ID: IJSDR2402013 Registration ID:209971 Published In: Volume 9 Issue 2, February-2024 DOI (Digital Object Identifier): Page No: 74 - 81 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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