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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Synthesis characterization and antimicrobial evaluation of indole based heterocyclic compounds |
| Authors Name: | Kalyani Shashikant Bokde , Mehta Parulben D |
| Unique Id: | IJSDR2402040 |
| Published In: | Volume 9 Issue 2, February-2024 |
| Abstract: | In the present work a few 2-phenylindole derivatives were synthesized and conjugated with thiadiazole nucleus via a linker and the compounds were assessed for their antimicrobial potential. The IR spectra of all the compounds exhibited the stretching vibration peaks due to C-N, C=C, C-H Ar, CH aliphatic at 1300-1100 cm-1, 1500-1700 cm-1, 3000-3200 cm-1 and 2600-3000 cm-1 respectively. The other vibrations that appeared in the spectra included those from C-O (1000-1100 cm-1), O-H (3200-3500 cm-1) and N-O (1400-1500 cm-1). The 1HNMR spectra obtained displayed the peaks of aliphatic CH and aromatic CH as well as peak of O-H in the corresponding compounds (4b, 4c). The mass spectra displayed the molecular ion peak and the isotopic peaks as calculated. The antimicrobial action of the synthesized compounds was testing using two bacteria, Escherichia coli and staphylococcus aureus. The standard drug norfloxacin and the test compounds 4e and 4a were found to significantly inhibit the growth of the microbes in culture medium presenting IC50 value of 66.94 µg/mL for E. coli and 62.21 µg/mL for S. aureus (4e) and 78.03 µg/mL for E. coli and 107.33 µg/mL for S. aureus (4a) |
| Keywords: | Indole, antimicrobial, thiadiazole, cup and plate, minimum inhibitory concentration |
| Cite Article: | "Synthesis characterization and antimicrobial evaluation of indole based heterocyclic compounds", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.9, Issue 2, page no.284 - 290, February-2024, Available :http://www.ijsdr.org/papers/IJSDR2402040.pdf |
| Downloads: | 000338719 |
| Publication Details: | Published Paper ID: IJSDR2402040 Registration ID:209982 Published In: Volume 9 Issue 2, February-2024 DOI (Digital Object Identifier): Page No: 284 - 290 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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