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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Recent advances in the chemistry and biology of naturally occurring antibiotics |
| Authors Name: | Mr. Mane Shantanu Rohidas , Ms. Dadewad Swapnali Sanjiv , Mr. Shinde Gopal Vinayak , Ms. Ingale Monika Balaji |
| Unique Id: | IJSDR2402089 |
| Published In: | Volume 9 Issue 2, February-2024 |
| Abstract: | Ever since the world-shaping discovery of penicillin, nature's molecular diversity has been extensively screened for new medications and lead compounds in drug discovery. Antibiotics markets are huge and the need for new classes of antibiotics is great, but the risks give investors pause. The search for agents intended to combat infectious diseases has been of particular interest and has enjoyed a high degree of success. Indeed, the history of antibiotics is marked with impressive discoveries and drug-development stories, the overwhelming majority of which have their origin in natural products. Chemistry, and in particular chemical synthesis, has played a major role in bringing naturally occurring antibiotics and their derivatives to the clinic, and no doubt these disciplines will continue to be key enabling technologies. In this review article, we highlight a number of recent discoveries and advances in the chemistry, biology, and medicine of naturally occurring antibiotics, with particular emphasis on total synthesis, analogue design, and biological evaluation of molecules with novel mechanisms of action. |
| Keywords: | medicines, natural products, synthesis, structure–property relationship, and antibiotics |
| Cite Article: | "Recent advances in the chemistry and biology of naturally occurring antibiotics", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.9, Issue 2, page no.576 - 587, February-2024, Available :http://www.ijsdr.org/papers/IJSDR2402089.pdf |
| Downloads: | 000338720 |
| Publication Details: | Published Paper ID: IJSDR2402089 Registration ID:210193 Published In: Volume 9 Issue 2, February-2024 DOI (Digital Object Identifier): Page No: 576 - 587 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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