INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15
The use of structure-based drug design, as opposed to the conventional approach, is becoming increasingly important for speedier and more valuable lead discovery. Research in the fields of structural, proteomic, and genomics has opened up countless new avenues for future drug discovery. Since rational, structure-based drug design employs the knowledge of the three-dimensional shape of the organic target within the technique and attempts to comprehend the molecular basis of a disease, it has been confirmed to be more environmentally friendly than traditional drug discovery methods. In this overview, We will also talk about the fundamental steps involved in SBDD as well as the tools used in it. and focus on the fundamentals and applications of virtual screening (VS) in the context of SBDD and investigate novel approaches, starting from the system's early stages, which include pre-processing receptors and libraries, and continuing through docking, scoring, and publish-processing of top coring hits. Structure-based total layout is one of the earliest methods used in drug design. The most recent advancements in structure-based total virtual screening (SBVS) performance via ensemble docking, brought about suit, and consensus docking are also mentioned.
Keywords:
Keywords: Structure- based drug discovery, Tools used for SBDD, Virtual screening, Molecular docking, Advances in SBDD.
Cite Article:
"Structure based Drug Design ", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.9, Issue 3, page no.259 - 268, March-2024, Available :http://www.ijsdr.org/papers/IJSDR2403040.pdf
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Publication Details:
Published Paper ID: IJSDR2403040
Registration ID:210350
Published In: Volume 9 Issue 3, March-2024
DOI (Digital Object Identifier):
Page No: 259 - 268
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631
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