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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Phytochemical pharmacotherapy for Parkinson`s disease: A comprehensive review on the current strategies |
| Authors Name: | M.Dhanalakshmi , Dr.G. Ariharasivakumar , M. Tamilarasan |
| Unique Id: | IJSDR2403097 |
| Published In: | Volume 9 Issue 3, March-2024 |
| Abstract: | Parkinson's disease (PD) is a chronic neurodegenerative illness that affects motor skills and cognitive ability. It is the second most common neurodegenerative disease. Motor symptoms, including dystonia, rigidity, bradykinesia, and tremors, are uncontrollable movements brought on by severe forms of Parkinson's disease. Non-motor symptoms like hysteria, sadness, constipation, and sleeplessness are also brought on by Parkinson's disease. Motor symptoms in Parkinson's disease are primarily caused by disruption of dopaminergic and non-dopaminergic neuronal networks in the substantia nigra pars compacta. The intricacy of pharmaceuticals crossing the blood-brain barrier contributes to the complexity of Parkinson's disease treatment. For the treatment of Parkinson's disease (PD), a number of conventional therapeutic modalities have been developed that just manage symptoms. Hence, a variety of ongoing studies are centred on the pursuit of novel compounds that may offer therapeutic advantages to individuals with Parkinson's disease. The objective is to review phytochemicals that have been shown to have preventive or therapeutic effects in Parkinson's disease (PD) in-depth before concentrating on the neuropsychopharmacology processes behind these effects. the many subgroups of the most prevalent classes of phytochemicals with proven antiparkinsonian properties, flavonoids, phenolic acids, and anthocyanins. Numerous mechanisms of action enable phytochemicals to exert their antiparkinsonian effects. These mechanisms include the suppression of apoptosis (through the reduction of Bax/Bcl-2, caspase-3, and α-synuclein accumulation), the reduction of proinflammatory gene expression, the reduction of dopaminergic neuronal loss and dopamine depletion, the modulation of nuclear and cellular inflammatory signalling, the elevation of neurotrophic factors, and the improvement of antioxidant status. To increase their effectiveness and lessen or eliminate their negative psychological effects in the treatment of Parkinson's disease (PD), a variety of plant-derived natural compounds may be used as pharmaceutical medications in the future or as an adjuvant treatment alongside traditional therapeutic procedure. In the management of neurodegenerative illnesses, well-designed recent clinical trials are just as promising as upcoming medications. These trials are required to assess the protective and restorative properties of phytochemicals. |
| Keywords: | Neurodegenerative, dystonia, rigidity, bradykinesia, tremors, hysteria |
| Cite Article: | "Phytochemical pharmacotherapy for Parkinson`s disease: A comprehensive review on the current strategies ", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.9, Issue 3, page no.663 - 673, March-2024, Available :http://www.ijsdr.org/papers/IJSDR2403097.pdf |
| Downloads: | 000337364 |
| Publication Details: | Published Paper ID: IJSDR2403097 Registration ID:210488 Published In: Volume 9 Issue 3, March-2024 DOI (Digital Object Identifier): Page No: 663 - 673 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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