INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15
Anticancer Drugs: Focus on Drug Discovery, Development, Clinical Research, and Pharmacoeconomics
Authors Name:
Amrit Bhalchandra Karmarkar
Unique Id:
IJSDR1704090
Published In:
Volume 2 Issue 4, April-2017
Abstract:
Cancer remains one of the top 10 causes of death in current era. It is disease caused by uncontrolled division or malignant growth of abnormal cells in the body. Although there are many drugs discovered so far, successful treatment and management of this disease is still not possible. Current review focuses on pathophysiology of cancers along with their types and risk factors. In current date, anticancer drugs are obtained from three different sources: plant, marine and monoclonal antibodies. Drug discovery process of selected anticancer molecules such as vincristine, vinblastine, paclitaxel, cytarabine, and monoclonal antibodies are discussed in detail. Pharmaceutical development of anticancer drugs, preclinical steps, and clinical trials are also discussed. Clinical end points used in oncology trials are explained. Economical analysis of anticancer drugs was reviewed using pharmacoeconomic parameters. Considering cost involved in development, cost of anticancer drugs in market is also very high as compared to drugs of other categories. There is need for discovery of drugs using specified molecular targets, with less developmental timeline and good clinical benefit so that cost of treatment could be decreased.
Keywords:
Cancer, Clinical Research, Pharmacoeconomics, Anticancer drugs, Drug discovery
Cite Article:
"Anticancer Drugs: Focus on Drug Discovery, Development, Clinical Research, and Pharmacoeconomics", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.2, Issue 4, page no.461 - 474, April-2017, Available :http://www.ijsdr.org/papers/IJSDR1704090.pdf
Downloads:
000337352
Publication Details:
Published Paper ID: IJSDR1704090
Registration ID:170306
Published In: Volume 2 Issue 4, April-2017
DOI (Digital Object Identifier): http://www.dx.doi.org/10.6084/m9.figshare.4929965
Page No: 461 - 474
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631
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