Overview of Antidote Therapy for Acute Paracetamol Poisoning

Suvarna Manoj Bhadane , Ms. Adiksha Mishra , Mr. Mohan kumar , Ms. Kajal Pawshe

Paracetamol, Antidotal activity, N-acetylcysteine, GSH precursors, Hepatic necrosis

The major target organ in paracetamol poisoning is the liver and the primary lesion is acute centrilobular hepatic necrosis. Without specific antidotal therapy, less than 10% would suffer severe liver damage but 1 to 2% will develop fulminant hepatic failure and this is often fatal. One to 2% of patients develop acute renal failure requiring dialysis. GSH precursors such as N-acetylcysteine have been found to be effective both in experimental animals and in humans N-acetylcysteine may reduce the severity of liver necrosis by directly conjugating with and/or reducing the reactive metabolite NAPQI. N-acetylcysteine has been shown to decrease the amount of paracetamol bound covalently to proteins, possibly by dissociation of the covalently bound paracetamol from proteins and or enhancing degradation of the arylated proteins. It appears to be safe to use intravenous N-acetylcysteine in these patients, and since they may benefit from this treatment, the use of N-acetylcysteine.

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"Overview of Antidote Therapy for Acute Paracetamol Poisoning", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.2, Issue 6, page no.391 - 396, June-2017, Available :https://ijsdr.org/papers/IJSDR1706059.pdf

Volume 2 Issue 6, June-2017

Pages : 391 - 396

Paper Reg. ID: IJSDR_170551

Published Paper Id: IJSDR1706059

Downloads: 000347360

Research Area: Pharmacy

Country: Kalyan East, Maharashtra, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR1706059

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR1706059

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

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