MEMORY ENHANCING ACTIVITY OF NERIUM INDICUM MILL STEM EXTRACTS IN RATS
Dr. Shrinivas K Sarje
, Aparna Suryavanshi , Pratiksha Alabade , Sohail Sk
Nerium indicum stem, Ethyl acetate and Ethanolic extract, Phytochemical screening, Memory enhancing activity
Memory is the ability of an individual to record sensory stimuli & retain them over short or long periods of time & recall the same at a later date when needed. Short and long term memory loss may result from deteriorating cerebral mechanisms due to different causes having impact on the quality of life. Memory enhancer can improve thinking, memory, and alertness in people with Alzheimers disease that affect the mind. The Stem of Nerium indicum mill belongs to the family apocynaceae is used as a digestive, laxative, anti-helmintic and are good for diarrhea, leprosy, dyspepsia and cough. Traditonally it is also used as Neuroprotective as it contains Chalcone derivatives. Memory refers to retaining and recalling information over a period of time, depending upon the nature of cognitive task you are required to perform. The present study designed to assess the memory enhancing potential of Nerium indicum stem extracts in wistar albino rats. In this study the two models has been selected under which in radial arm maze model in rats is used to evaluate working and reference memory errors and the Morris water maze is used to evaluate the retrieval of memory. The extract was administered orally in two doses (100 and 200 mg/kg p.o) for a period of 8 days for radial arm and 11 days for water maze test. Piracetam, 200mg/kg i.p, was used as standard drug treatment. Radial arm maze (RAM) was used to evaluate number of correct entries and time spent in baited arms as well as the latency to find the food. In Morris water maze used to evaluate the escape latency and time spent in target quadrant. The both the extracts of Nerium indicum at conc.200mg/kg, o.p. showed significantly increase in number correct entries and time spent in baited arms as well as increase in latency to find food, besides this in Morris water maze both the extracts i.e NIEA200 and NIETH-200 mg/kg, o.p. showed significantly decreased in escape latency and increased in time spent in target quadrants as compared to standard (Pirecetam) and highly significant difference when compared to control. The present study revealed that the Nerium indicum stem extracts has potential to enhance the Memory and this might be due to presence of flavones and chalcone deriavtives such as Pongone, galbone, Pongalabol etc.
"MEMORY ENHANCING ACTIVITY OF NERIUM INDICUM MILL STEM EXTRACTS IN RATS", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.5, Issue 9, page no.216 - 224, September-2020, Available :https://ijsdr.org/papers/IJSDR2009036.pdf
Volume 5
Issue 9,
September-2020
Pages : 216 - 224
Paper Reg. ID: IJSDR_192435
Published Paper Id: IJSDR2009036
Downloads: 000347218
Research Area: Pharmacy
Country: Nanded, Maharashtra, India
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
