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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | PHYTOCHEMICAL INVESTIGATION AND PHARMACOLOGICAL EVALUATION OF TRIGONELLA FOENUM-GRAECUM LEAVES EXTRACTS FOR ITS WOUND HEALING ACTIVITY |
| Authors Name: | Dr. Shrinivas K Sarje , Sharada Yenglod , Arti Shembade , Sourabh Atak |
| Unique Id: | IJSDR2009037 |
| Published In: | Volume 5 Issue 9, September-2020 |
| Abstract: | The present study reports physicochemical characterization, antioxidant, antimicrobial and Wound Healing activity of extracts from Trigonella Foenum-graecum leaves collected from local region of Nanded, Maharashtra, India. The extracts were obtained from Soxhlet method by using ethyl acetate and methanol as solvents for extraction and subjected for preliminary physicochemical evaluation and antioxidant studies. Total phenolic and flavonoids content were also analyzed. The presence of primary and secondary metabolites such as carbohydrate, amino acids, tannins, alkaloids, phenolic compounds, saponins were confirmed through preliminary phyto-chemical analysis. DPPH free radical scavenging assays showed strong antioxidant activities with increase in concentration of Ethyl acetate and methanol leaves extracts. Maximum percentage inhibition i.e. 80.97% was shown by Ethyl acetate extract at concentration of 150 μg/ml and was compared with Ascorbic acid as reference standard. The in vitro Antibacterial property of Trigonella Foenum-graecum leaves was carried out by using agar cup and plate method. In this method, increase in zone of inhibition was Ethyl acetate extract having better antibacterial activity on Baccilus substillus than Staphylococcus aureus & E.coli. Methanol extract having better antibacterial activity against Baccilus substillus & Staphylococcus aureus than E.coli Antifungal property of Trigonella Foenum-graecum leaves was carried out by using poison plate method. In this method, reducing growth of fungi (moderate antifungal activity) and no growth of fungi of test sample was calculated and compared with standard i.e. (Griseofulvin). Both extract showed the reduced growth (more than 50% and less than 90% reduction in growth) at 100 mg/ml. The In-Vivo Wound Healing activity of Trigonella Foenum-graecum leaves was evaluated by excision wound model in rats using Soframycin as standard. Both the extracts at 5 % concn showed significant reduction in wound size. The result suggest that Trigonella Foenum-graecum leaves extracts possess wound healing activity and this might be due to flavonoids, Phenolic compound, coumarin, tannin and saponins present in extract. |
| Keywords: | Trigonella Foenum-graecum, Ethyl acetate and Methanolic extract, Phytochemical screening, Antioxidant effect, Anti-microbial activity, Wound healing activity. |
| Cite Article: | "PHYTOCHEMICAL INVESTIGATION AND PHARMACOLOGICAL EVALUATION OF TRIGONELLA FOENUM-GRAECUM LEAVES EXTRACTS FOR ITS WOUND HEALING ACTIVITY ", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.5, Issue 9, page no.225 - 236, September-2020, Available :http://www.ijsdr.org/papers/IJSDR2009037.pdf |
| Downloads: | 000337072 |
| Publication Details: | Published Paper ID: IJSDR2009037 Registration ID:192436 Published In: Volume 5 Issue 9, September-2020 DOI (Digital Object Identifier): Page No: 225 - 236 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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