PARP inhibitors in various cancers
PARP, BER, SSB, DSB, BRCA, Cytotoxicity, chemotherapy, Homologous recombination.
Poly (ADP-ribose) polymerase which is component of DNA repair processes, especially base excision repair (BER). SSBs in DNA are repaired by BER. SSBs aggregate and create double stand breaks when BER is suppressed, which inhibits PARP. Alternative repair processes, including as nonhomologous end joining and homologous recombination (HR), become more important as the frequency of DSBs increases. Patients with a faulty HR, such as BRCA deficient cell lines, are highly sensitive to BER pathway disruption. PARP inhibitors destroy cancer cells in BRCA mutant cancer cell lines more effectively than normal cancer cell lines. PARPi also enhance cytotoxicity by limiting repair in the context of SSB-generating chemotherapies. In a clinical environment, these two ideas were put to the test. Because of its shown efficacy as a single agent in BRCA1 or BRCA2 related ovarian or breast malignancies, as well as in conjugation with chemotherapy in triple negative breast cancer, interest in this class of drugs has risen in recent years. This article addresses the mechanism of PARPi and their involvement in different Cancers.
"PARP inhibitors in various cancers", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.6, Issue 6, page no.273 - 279, June-2021, Available :https://ijsdr.org/papers/IJSDR2106043.pdf
Volume 6
Issue 6,
June-2021
Pages : 273 - 279
Paper Reg. ID: IJSDR_193441
Published Paper Id: IJSDR2106043
Downloads: 000347181
Research Area: Biological Science
Country: Vadodara, Gujarat, India
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
