INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15
The enantiomeric purity of luliconazole, this method was developed to perform with comparative study. This method was based on luliconazole and its isomers can be derivatised with Isomer-II i.e. (-)- (Z)-2-[4(R)-2,4-Dichlorophenyl)- 1,3 -dithiolan-2-ylidene]-2 -(1 H-imidazole- 1 -yl) acetonitrile or Z Isomer. The derivatised compounds can be separated by a chromatography column Phenomenex ceollose – 1 ,250 × 4.6, 5µm, n-Hexane: Ethanol (90:10) used as mobile phase and 1.0 ml/min flow rate at room temperature. Injection volume is 10 µl and run time is 60 min. The detective wavelength is fixed at 215nm. The result indicates the limit of Z isomer complying the quality. [Limit: Z isomer NMT 0.15%], the purity of luliconazole was found to be 99.83%. Repeatability and accuracy are satisfied. This article is generated with aim and review of check analytical chiral purity of luliconazole by HPLC.
Keywords:
Luliconazole, Enantiomeric purity, Derivatised, Normal phase, Chiral
Cite Article:
"Determination of Enantiomeric Purity of Luliconazole by Normal Phase HPLC", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.7, Issue 5, page no.291 - 293, May-2022, Available :http://www.ijsdr.org/papers/IJSDR2205055.pdf
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000337214
Publication Details:
Published Paper ID: IJSDR2205055
Registration ID:200367
Published In: Volume 7 Issue 5, May-2022
DOI (Digital Object Identifier):
Page No: 291 - 293
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631
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