|
INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
Imp Links for Author
Imp Links for Reviewer
Research Area
Subscribe IJSDR
Visitor Counter
Copyright Infringement Claims
Indexing Partner
|
Published Paper Details
|
|
| Paper Title: | Formulation and in-vitro evaluation of long circulating coated vitamin ETPGS phytosomes of docetaxel |
| Authors Name: | Vibha Sharma , Anu Pawar |
| Unique Id: | IJSDR2209121 |
| Published In: | Volume 7 Issue 9, September-2022 |
| Abstract: | Docetaxel (DCX) is a highly effective chemotherapeutic drug used in the treatment of different types of cancer, including non-small cell lung cancer. The drug is known to have low oral bioavailability due to its low aqueous solubility, poor membrane permeability and susceptibility to hepatic first-pass metabolism. To mitigate these problems, DCX is administered via the intravenous route. Coated vitamin ETPGS loaded phospholipid complex (phytosomes) was formulated by solvent evaporation method. .A new, simple, rapid , economical and sensitive UV - Spectrophotometric method has been developed for the estimation of docetaxel .The maximum wavelength of docetaxel was observed at 228 nm over the concentration range of 2 to 32μg/ml with R² = 0.9997. The formulations was characterized for particle size, zeta potential, entrapment efficiency, FTIR (Fourier transformed infrared), TEM (transmission electron microscopy) and drug release properties In-vitro drug release studies were carried out in phosphate buffer saline (pH 7.4) using dialysis bag method. The results indicates that the shape and size of the optimized (F2) formulation was confirmed through microscope and particle size and zeta potential found that most of the particles were well identified. After selecting the best formulation (F2) different concentrations (0.01 ,0.03, 0.05%) of vitamin ETPGS was added to the formulation (F5-F7) for coating of phytosome. The optimum formulation was selected further depending upon the particle size and entrapment efficiency of the prepared formulations and was found to be (F6) 86.6±0.0443%. The coated vitamin ETPGS formulation batch FD6 has particle size 166.23nm with PDI 305.3, zeta potential in range of 166.23nm with PDI 305.3. TEM & FTIR data show that the selected drug and excipients were chemically compatible. The results showed that the drug release of F6 formulation followed Higuchi order which describes that the docetaxel follows a sustain mechanism for release of coated vitamin ETPGS phytosome of docetaxel upto to72 hours. |
| Keywords: | docetaxel, phytosomes, vitamin, ETPGS, cancer |
| Cite Article: | "Formulation and in-vitro evaluation of long circulating coated vitamin ETPGS phytosomes of docetaxel", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.7, Issue 9, page no.763 - 779, September-2022, Available :http://www.ijsdr.org/papers/IJSDR2209121.pdf |
| Downloads: | 000337070 |
| Publication Details: | Published Paper ID: IJSDR2209121 Registration ID:201797 Published In: Volume 7 Issue 9, September-2022 DOI (Digital Object Identifier): Page No: 763 - 779 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
|
Click Here to Download This Article |
|
| Article Preview | |
|
|
|
Major Indexing from www.ijsdr.org
| Google Scholar | ResearcherID Thomson Reuters | Mendeley : reference manager | Academia.edu |
| arXiv.org : cornell university library | Research Gate | CiteSeerX | DOAJ : Directory of Open Access Journals |
| DRJI | Index Copernicus International | Scribd | DocStoc |
Track Paper
Important Links
Conference Proposal
ISSN
 |
 |
DOI (A digital object identifier)
  Providing A digital object identifier by DOI How to GET DOI and Hard Copy Related |
Open Access License Policy
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
|
 |
 |
 |
Social Media
Indexing Partner |
|||
| Copyright © 2024 - All Rights Reserved - IJSDR | |||
Facebook Twitter Instagram LinkedIn