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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH
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ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
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Paper Title:	Prevalence of Oropharyngeal Candidiasis In Human Immunodeficiency Virus Infected Patients Attending The Government Hospital
Authors Name:	DR Darshana M V , Dr Shyamala R , Dr Naseema Tabaseera , Dr Lokesh A J , Dr Sreedevi H, Dr Pradhyumn G K
Unique Id:	IJSDR2211006
Published In:	Volume 7 Issue 11, November-2022
Abstract:	ABSTRACT Background: HIV patients are prone for getting Candida infection especially in the mucosal area like oral cavity and pharynx. Candida albicans is the main yeast causing oral infections. Recurrent infections in the mucosa are unavoidable when HIV patients are put on antibiotics or corticosteroids therapy and smoking itself is a risk factor resulting in transition of commensal phase Candida to pathogenic, though exact reason is not found. Aim : To isolate, speciate and test for anti-fungal drugs against Candida species. Methodology: HIV was tested as per the NACO guidelines at our ICTC. Mycological study was conducted using oral swabs smeared from white patch over tongue, palate and gums. Sabourauddextrose agar was used to culture yeasts.Cream pasty colonies found were subjected for Candida speciation and characterization by standard identification methods. Fluconazole disks (10µg), Voriconazole disks (1µg) was used for anti-fungal susceptibility testing. Results: Prevalence of OPC is about 69.09%. Candida albicans (59 - 77.66%) was the predominant isolate in our study. 27 of 35 isolates were C. albicans under200 cells/mm3CD4 count. And seven C.albicanswere isolated among >500 cells/mm3. All Candida species showed resistance to Fluconazole. Voriconazole was sensitive in 82.4% species and resistant in 17.6% of isolates. Conclusion: C. albicans remains the most frequently isolated yeast causing oral thrush. There is changing trends of causative role of non-albicans in causing Oropharyngeal candidiasis (OPC) which are resistant to azole drug fluconazole. ART significantly reduces the occurrence of OPC. Lower CD4 count shows increased colonization of pathological organisms.
Keywords:	HIV patients, Oropharyngeal candidiasis, Candia Albicans, Non Candida Albicans, Antifungal susceptibility, Fluconazole, Voriconazole
Cite Article:	"Prevalence of Oropharyngeal Candidiasis In Human Immunodeficiency Virus Infected Patients Attending The Government Hospital ", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.7, Issue 11, page no.32 - 35, November-2022, Available :http://www.ijsdr.org/papers/IJSDR2211006.pdf
Downloads:	000337067
Publication Details:	Published Paper ID: IJSDR2211006 Registration ID:201164 Published In: Volume 7 Issue 11, November-2022 DOI (Digital Object Identifier): http://doi.one/10.1729/Journal.32002 Page No: 32 - 35 Publisher: IJSDR \| www.ijsdr.org ISSN Number: 2455-2631

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