Prevalence of Oropharyngeal Candidiasis In Human Immunodeficiency Virus Infected Patients Attending The Government Hospital
DR Darshana M V
, Dr Shyamala R , Dr Naseema Tabaseera , Dr Lokesh A J , Dr Sreedevi H, Dr Pradhyumn G K
HIV patients, Oropharyngeal candidiasis, Candia Albicans, Non Candida Albicans, Antifungal susceptibility, Fluconazole, Voriconazole
ABSTRACT Background: HIV patients are prone for getting Candida infection especially in the mucosal area like oral cavity and pharynx. Candida albicans is the main yeast causing oral infections. Recurrent infections in the mucosa are unavoidable when HIV patients are put on antibiotics or corticosteroids therapy and smoking itself is a risk factor resulting in transition of commensal phase Candida to pathogenic, though exact reason is not found. Aim : To isolate, speciate and test for anti-fungal drugs against Candida species. Methodology: HIV was tested as per the NACO guidelines at our ICTC. Mycological study was conducted using oral swabs smeared from white patch over tongue, palate and gums. Sabourauddextrose agar was used to culture yeasts.Cream pasty colonies found were subjected for Candida speciation and characterization by standard identification methods. Fluconazole disks (10µg), Voriconazole disks (1µg) was used for anti-fungal susceptibility testing. Results: Prevalence of OPC is about 69.09%. Candida albicans (59 - 77.66%) was the predominant isolate in our study. 27 of 35 isolates were C. albicans under200 cells/mm3CD4 count. And seven C.albicanswere isolated among >500 cells/mm3. All Candida species showed resistance to Fluconazole. Voriconazole was sensitive in 82.4% species and resistant in 17.6% of isolates. Conclusion: C. albicans remains the most frequently isolated yeast causing oral thrush. There is changing trends of causative role of non-albicans in causing Oropharyngeal candidiasis (OPC) which are resistant to azole drug fluconazole. ART significantly reduces the occurrence of OPC. Lower CD4 count shows increased colonization of pathological organisms.
"Prevalence of Oropharyngeal Candidiasis In Human Immunodeficiency Virus Infected Patients Attending The Government Hospital ", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.7, Issue 11, page no.32 - 35, November-2022, Available :https://ijsdr.org/papers/IJSDR2211006.pdf
Volume 7
Issue 11,
November-2022
Pages : 32 - 35
Paper Reg. ID: IJSDR_201164
Published Paper Id: IJSDR2211006
Downloads: 000347173
Research Area: Medical Science
Country: Chikmagalor, Karnataka, India
DOI: http://doi.one/10.1729/Journal.32002
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
