Preparation, Development and Evaluation of Spherical Poly Electrolyte Coacervates of Zidovudine Prepared by Emulsification Method
Kotresh Yaligar
, B.Madhulatha
Acacia, Chitosan, Sodium alginate, Zidovudine
The objective of the present work is to prepare spherical polyelectrolyte microcapsules of Zidovudine by a means of complex coacervation method in an emulsion system. Chitosan was used as the cationic polymer and sodium alginate and acacia as the anionic polymers. The two polymers were made to interact at a concentration of 2% and the coacervation was achieved at pH6.8. Glutaraldehyde was used as the cross linking agent. Microspheres were prepared in drug to polymer ratios of 0.5:1, 0.75:1 and 1:1. Microsphere suspension in arachis oil was prepared in ratio of 0.5:1. The emulsification used for microparticle formation allows the preparation of particles with spherical shape and narrow size distribution. The suspension was better than the dry product with respect to shape, drug content and also order of release, which was zero order for suspension whereas first order for the dried product. The drug from the suspension formulation was found to release over a period of 10hrs. The oily suspension provides a means of parenteral administration of Zidovudine, provided the particle size can be further reduced. This sustained release parenteral formulation of Zidovudine would be beneficial in comparison with the current intermittent oral dosage regimen.
"Preparation, Development and Evaluation of Spherical Poly Electrolyte Coacervates of Zidovudine Prepared by Emulsification Method", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.7, Issue 11, page no.357 - 372, November-2022, Available :https://ijsdr.org/papers/IJSDR2211059.pdf
Volume 7
Issue 11,
November-2022
Pages : 357 - 372
Paper Reg. ID: IJSDR_202499
Published Paper Id: IJSDR2211059
Downloads: 000347197
Research Area: Pharmacy
Country: Hyderabad, Telangana , India
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
