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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Evaluation of anti-epileptic activity of hydroalcoholic extract of Citrus maxima fruit peel in experimental mice |
| Authors Name: | Ayesha Nazeer , Ashoka Shenoy M. |
| Unique Id: | IJSDR2212137 |
| Published In: | Volume 7 Issue 12, December-2022 |
| Abstract: | The antiepileptic activity of Citrus maxima fruit-peel extract (CMPE) was analysed using Maximal Electro-shock and Pentylenetetrazole induced convulsion models in Swiss albino mice. The mice were divided into 4 groups with 6 animals each. Group I were treated with vehicle (oral, p.o.) as control, Group II received standard drugs Phenytoin (25mg/kg, i.p.) for Maximal electro-shock model or Diazepam (4mg/kg, intraperitoneal, i.p.) for Pentylenetetrazole model, Group III and Group IV consisted of animals treated with 200mg/kg, (p.o.) and 400mg/kg, (p.o.) of the extract. All the treatments were given for 14 days. On the 14th day the convulsions were induced in all the study groups. The hydroalcoholic extract of the fruit-peel of Citrus maxima (Pomelo) (CMPE) at both doses (200mg/kg and 400mg/kg, p.o.) demonstrated a significant reduction in Hind Limb Tonic Extension (HLTE) phase duration in MES-induced model. They exhibited a dose-dependent action but with only a slight improvement of activity in the higher dosage group in this model. The extracts showed highly significant, dose-dependent antiepileptic activity in PTZ-induced model by comparing the parameters with the control group, such as delay in onset, reduction in duration of convulsions and decrease in mortality rate. In conclusion, Hydroalcoholic extract of Citrus maxima fruit-peel has considerable protective action against Maximal electro-shock and Pentylenetetrazole induced convulsions in mice when studied for its antiepileptic potential. |
| Keywords: | Pentylenetetrazole, Antiepileptic, Citrus maxima, Convulsions, Maximal electro-shock, Hydroalcoholic, Phenytoin, Diazepam. |
| Cite Article: | "Evaluation of anti-epileptic activity of hydroalcoholic extract of Citrus maxima fruit peel in experimental mice", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.7, Issue 12, page no.881 - 888, December-2022, Available :http://www.ijsdr.org/papers/IJSDR2212137.pdf |
| Downloads: | 000337209 |
| Publication Details: | Published Paper ID: IJSDR2212137 Registration ID:203065 Published In: Volume 7 Issue 12, December-2022 DOI (Digital Object Identifier): Page No: 881 - 888 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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