Evaluation of anti-epileptic activity of hydroalcoholic extract of Citrus maxima fruit peel in experimental mice
Ayesha Nazeer
, Ashoka Shenoy M.
Pentylenetetrazole, Antiepileptic, Citrus maxima, Convulsions, Maximal electro-shock, Hydroalcoholic, Phenytoin, Diazepam.
The antiepileptic activity of Citrus maxima fruit-peel extract (CMPE) was analysed using Maximal Electro-shock and Pentylenetetrazole induced convulsion models in Swiss albino mice. The mice were divided into 4 groups with 6 animals each. Group I were treated with vehicle (oral, p.o.) as control, Group II received standard drugs Phenytoin (25mg/kg, i.p.) for Maximal electro-shock model or Diazepam (4mg/kg, intraperitoneal, i.p.) for Pentylenetetrazole model, Group III and Group IV consisted of animals treated with 200mg/kg, (p.o.) and 400mg/kg, (p.o.) of the extract. All the treatments were given for 14 days. On the 14th day the convulsions were induced in all the study groups. The hydroalcoholic extract of the fruit-peel of Citrus maxima (Pomelo) (CMPE) at both doses (200mg/kg and 400mg/kg, p.o.) demonstrated a significant reduction in Hind Limb Tonic Extension (HLTE) phase duration in MES-induced model. They exhibited a dose-dependent action but with only a slight improvement of activity in the higher dosage group in this model. The extracts showed highly significant, dose-dependent antiepileptic activity in PTZ-induced model by comparing the parameters with the control group, such as delay in onset, reduction in duration of convulsions and decrease in mortality rate. In conclusion, Hydroalcoholic extract of Citrus maxima fruit-peel has considerable protective action against Maximal electro-shock and Pentylenetetrazole induced convulsions in mice when studied for its antiepileptic potential.
"Evaluation of anti-epileptic activity of hydroalcoholic extract of Citrus maxima fruit peel in experimental mice", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.7, Issue 12, page no.881 - 888, December-2022, Available :https://ijsdr.org/papers/IJSDR2212137.pdf
Volume 7
Issue 12,
December-2022
Pages : 881 - 888
Paper Reg. ID: IJSDR_203065
Published Paper Id: IJSDR2212137
Downloads: 000347262
Research Area: Engineering
Country: -, -, --
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
