Formulation and evaluation of pulsatile drug delivery system of atorvastatin using press coating technique

Manjula R. , Keerthi H. S. , Shivanand K. Mutta , Sowmya T. P. , Pradeep Kumar Patel

Pulsatile drug delivery system, hypercholesterolemia, circadian rhythm, Atorvastatin.

The objective of present investigation is to formulate and evaluate press coated tablet for pulsatile drug delivery system of Atorvastatin, which can be taken at bed time (10pm) and capable of releasing the drug between night and early morning hours after predetermined time delay (4 hr), when free cholesterol levels are more prevalent, can prevent various heart diseases like atherosclerosis, stroke, angina and myocardial infarction. The rationale of this study is to achieve sequential release of Atorvastatin that suits the biological requirement (circadian rhythm) of hypercholesterolemia. The press coated tablets containing Atorvastatin have been made by incorporating crosspovidone by direct compression method with an outer coating of different ratios of Xanthun gum and guar gum. The disintegration time and percentage drug release was analysed for all prepared tablets from each formulation. Drug excipients compatibility has been studied by FT-IR spectroscopic studies. The formulated tablets were evaluated by stability, friability, drug content uniformity tests. Result of in-vitro dissolution study of the formulated tablet was suggested that, the release of drug from pulsatile unit match with the chronobiological requirement of disease.

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"Formulation and evaluation of pulsatile drug delivery system of atorvastatin using press coating technique ", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.7, Issue 12, page no.1048 - 1051, December-2022, Available :https://ijsdr.org/papers/IJSDR2212166.pdf

Volume 7 Issue 12, December-2022

Pages : 1048 - 1051

Paper Reg. ID: IJSDR_203209

Published Paper Id: IJSDR2212166

Downloads: 000347221

Research Area: Pharmacy

Country: Bangalore, Karnataka, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2212166

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2212166

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

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